Uses
Ethylene dimethane sulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs[1].
Biological Activity
Ethylene dimethanesulfonate is a mild alkylated ethylene glycol nonvolatile methanesulfonate diester. It has a selective pro-apoptotic effect on LC.
in vivo
Ethylene dimethanesulfonate (subcutaneous injection; 75 mg/kg; 7 days) disrupts epididymal function and leads to sperm granuloma formation in rat.
References
[1] Dutta D, et al. Ethylene dimethane sulfonate (EDS) ablation of Leydig cells in adult rat depletes testosterone resulting in epididymal sperm granuloma: Testosterone replacement prevents granuloma formation. Reprod Biol. 2019 Mar;19(1):89-99. DOI:
10.1016/j.repbio.2018.11.005
