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Dalfopristin

Dalfopristin Structure
Dalfopristin
  • CAS No.112362-50-2
  • Chemical Name:Dalfopristin
  • CBNumber:CB31075198
  • Molecular Formula:C34H50N4O9S
  • Formula Weight:690.85
  • MOL File:112362-50-2.mol
Dalfopristin Property
  • Melting point ~150°
  • Boiling point 940.5±65.0 °C(Predicted)
  • Density 1.27±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO:113.0(Max Conc. mg/mL);163.57(Max Conc. mM)
    Ethanol:100.0(Max Conc. mg/mL);144.75(Max Conc. mM)
  • form Solid
  • pka 13.18±0.70(Predicted)
  • color White to yellow
  • FDA UNII R9M4FJE48E
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Dalfopristin Chemical Properties,Usage,Production

  • Uses A Viiginiamycin M1 (V672810) derivative. A streptogramin antibiotic used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium.
  • Uses Dalfopristin is a semi-synthetic analogue of ostreogrycin A (virginiamycin M, pristinamycin IIA, streptogramin A) formed by addition of diethylaminoethylthiol to the 2-pyrroline group of ostreogrycin, followed by oxidation to the sulfone. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Dalfopristin is used commercially in synergistic combination with quinupristin (70:30). There is little published data on the synthesis, biological or antibiotic activity of dalfopristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
  • Uses Dalfopristin is a semi-synthetic analogue of ostreogyrcin A (virginiamycin M, pristinamycin IIA, streptogramin A) formed by addition of diethylaminoethylthiol to the 2-pyrroline group of ostreogyrcin, followed by oxidation to the sulphone. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Dalfopristin is used commercially in synergistic combination with quinupristin (70:30). There is little published data on the synthesis, biological or antibiotic activity of dalfopristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
  • Definition ChEBI: Dalfopristin is a macrolide that is pristinamycin IIA in which the double bond between positions 26 and 26a of the pyrroline ring has been reduced and position 26R carries a [2-(diethylamino)ethyl]sulfonyl group. It is a semi-synthetic streptogramin antibiotic and often used as a mixture with quinupristin for the treatment of vancomycin-resistant Enterococcus faecium. It has a role as an antibacterial drug and a protein synthesis inhibitor. It is a macrolide, a member of 1,3-oxazoles, a cyclic ketone, an enamide, a secondary alcohol, a secondary carboxamide, a tertiary carboxamide, a sulfone, a tertiary amino compound, a carboxylic ester and a macrolide antibiotic. It is functionally related to a pristinamycin IIA.
  • in vivo

    Dalfopristin (12 mg/kg/day, i.v., 7 days) shows no effects on hepatic cytochrome P-450 metabolite complexes in rats[2].

Dalfopristin Preparation Products And Raw materials
Raw materials
Preparation Products
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Dalfopristin Spectrum
112362-50-2, DalfopristinRelated Search:
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  • C34H50N4O9S
  • 达福普汀,10 MM DMSO 溶液
  • 甲磺酸达福司汀
  • (1(2)Z,3(2)S,3(3)R,6R,7R,17S)-3(3)-((2-(二乙氨基)乙基)磺酰基)-17-羟基-6-异丙基-7,15-二甲基-5-氧杂-11-氮杂-1(4,2)-噁唑-3(1,2)-吡咯烷酰基二十碳六烯酸-8,13,15-三烯-2,4,10,19-四酮
  • (3R,4R,5E,10E,12E,14S,26R,26AS)-26-[[2-(二乙氨基)乙基]磺酰基]-8,9,14,15,24,25,26,26A-八氢-14-羟基-4,12-二甲基-3-(1-甲基乙基)-3H-21,18-腈-1H,22H-吡咯并[2,1-C][1,8,4,19] DIOXADIAZAZACYCLOTETRACOSINE-1,7,16,22(4H,17H)-四酮
  • 达福司汀杂质
  • 达福司汀
  • 达福普丁甲磺酸
  • 达福普汀
  • 112362-50-2
  • Dalfopristin, 10 mM in DMSO
  • RP-54476,RP 54476,Inhibitor,Dalfopristin,Antibiotic,Bacterial,inhibit
  • (3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(Diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone
  • 3H-21,18-Nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone, 26-[[2-(diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-, (3R,4R,5E,10E,12E,14S,26R,26aS)-
  • (3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(Diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadi
  • Dalfopristin
  • RP 54476
  • Dalfopristin Mesylate
  • (3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(DiethylaMino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-diMethyl-3-(1-Methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetr

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