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LONAFARNIB

LONAFARNIB Structure
LONAFARNIB
  • CAS No.193275-84-2
  • Chemical Name:LONAFARNIB
  • CBNumber:CB31011743
  • Molecular Formula:C27H31Br2ClN4O2
  • Formula Weight:638.82
  • MOL File:193275-84-2.mol
LONAFARNIB Property
  • Melting point 214.5-215.9° (monohydrate); mp 222-223°
  • alpha D25 = +49.1° (c = 0.21 in methanol)
  • Boiling point 710.4±70.0 °C(Predicted)
  • Density 1.536
  • storage temp. -20°C
  • solubility Chloroform (Slightly), Methanol (Slightly)
  • form powder
  • pka 15.76±0.40(Predicted)
  • color white to beige
  • NCI Dictionary of Cancer Terms lonafarnib; SCH 66336
  • FDA UNII IOW153004F
  • NCI Drug Dictionary lonafarnib
  • UNSPSC Code 12352200
  • NACRES NA.77
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338
LONAFARNIB Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1457
  • Product name : Lonafarnib
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹13531.25
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1457
  • Product name : Lonafarnib
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹54428.1
  • Updated: 2022/06/14
  • Buy: Buy

LONAFARNIB Chemical Properties,Usage,Production

  • Uses Lonafarnib is an orally bioavailable tricyclic inhibitor of farnesyl protein transferase. It inhibits Rheb farnesylation and mTOR signaling and enhances taxane and tamoxifen antitumor activity. Studies show that it induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells
  • Uses Chemotherapeutic (farnesyl transfer ase inhibitor).
  • Definition ChEBI: A 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide that has R configuration. It is used as oral farnesyltransferase nhibitor.
  • General Description Lonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI). K- and N-Ras are substrates of farnesyl transferase.
  • Biological Activity lonafarnib (sch66336, sarasar) is an potent, selective, orally, bioavailable tricyclic nonpeptidyl nonsulfhydry inhibitor of farnesyltransferase (ftase).[1] it is a small molecular with the formula of c27h31br2cln4o2 and molecular weight of 638.82. farnesylated ras proteins was found to regulate signal transduction pathways which drive cell proliferation, growth and survival and be required for its membrane localization.[1, 2] lonafarnib inhibits the post-translational farnesylcation of ras proteins, therefore blocking translocation of ras to the plasma membrane.[3][1] eric w, malcolm j. m, kim n. c, d. scott e, et al. a multinomial phase ii study of lonafarnib (sch 66336) in patients with refractory urothelial cancer. urologic oncology: seminars and original investigations. 2005, 23. 143-149.[2] gongjie l, stacey a. t, cindy h. m, yunsheng h, w. robert b, et al. continuous and intermittent dosing of lonafarnib potentiates the therapeutic efficacy of docetaxel on preclinical human prostate cancer models. int. j. cancer. 2009, 125. 2711–2720.[3] vasiliki a. n, alexander j. s, keith t. f, hensin t, et al. melanoma: new insights and new therapies. j invest dermatol. 2012, 132. 854–863.
  • Biochem/physiol Actions Lonafarnib prevents the post-translational lipid modification of H-Ras and other farnesylated proteins. Lonafarnib treatment results in microtubule bundling, increased microtubule acetylation and stabilization and suppression of microtubule dynamics.
  • Mechanism of action Lonafarnib is a protein farnesyltransferase inhibitor (FTI) that reversibly binds to the farnesyltransferase CAAX binding site9, thereby inhibiting progerin farnesylation and subsequent intercalation into the nuclear membrane.
  • Side effects
    • vomiting
    • diarrhea
    • nausea
    • stomach pain
    • constipation
    • gas
    • decreased appetite
    • decreased weight
  • target FT
  • storage Store at -20°C
LONAFARNIB Preparation Products And Raw materials
Raw materials
Preparation Products
LONAFARNIB Suppliers
Global(164)Suppliers
  • Supplier：
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LONAFARNIB Spectrum
193275-84-2, LONAFARNIBRelated Search:
  • APIs
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Inhibitors
  • Heterocycles
  • Aromatics
  • Inhibitor
  • 药靶配体
  • 合成有机化合物配体
  • 抑制剂
  • 标准品
  • 细胞生物学试剂
  • 代谢
  • 小分子抑制剂，天然产物
  • 氯那法尼,10 MM DMSO 溶液
  • 洛那法尼布
  • (R)-4-[2-[4-[3,10-二溴-8-氯-6,11-二氢-5H-苯并[5,6]环庚并[1,2-B]吡啶-11-基]-1-哌啶基]-2-氧代乙基]-1-哌啶甲酰胺
  • 4-[2-[4-[(11R)-3,10-二溴-8-氯-6,11-二氢-5H-苯并[5,6]环庚并[1,2-B]吡啶-11-基]-1-哌啶基]-2-氧代乙基]-1-哌啶甲酰胺 5级
  • FPTASE抑制剂(LONAFARNIB)
  • 洛那法尼(抗癌类抗白血病药)
  • 氯那法尼
  • 洛那法尼
  • 4-[2-[4-[(11R)-3,10-二溴-8-氯-6,11-二氢-5H-苯并[5,6]环庚并[1,2-B]吡啶-11-基]-1-哌啶基]-2-氧代乙基]-1-哌啶甲酰胺
  • 193275-84-2
  • Lonafarnib, 10 mM in DMSO
  • Valine Impurity 114
  • Lonafarnib Sarasar SCH 66336
  • LONAFARNIB USP/EP/BP
  • SCH-066336
  • EOS-61911
  • SARASAR; SCH 66336; SCH66336; SCH-66336
  • 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
  • ( )4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta (1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxami de
  • (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide
  • LonafarMib
  • 1-PiperidinecarboxaMide, 4-[2-[4-[(11R)-3,10-dibroMo-8-chloro-6
  • 4-[2-[4-[(11R)-3,10-DibroMo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-
  • Unii-iow153004f
  • Sch66336
  • Sch 66336
  • Sarasar
  • Lonafarnib [usan]
  • 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-B)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide
  • 1-Piperidinecarboxamide, 4-(2-(4-((11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-B)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-
  • Lonafarnib (SCH66336)
  • 4-(2-(4-((R)-3,10-dibroMo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)cyclohexyl)-2-oxoethyl)piperidine-1-carboxaMide
  • LONAFARNIB

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