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2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Structure
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
  • CAS No.35604-67-2
  • Chemical Name:2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
  • CBNumber:CB2933621
  • Molecular Formula:C13H20ClNO3
  • Formula Weight:273.7558
  • MOL File:35604-67-2.mol
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Property
  • Melting point 178-180°C
  • storage temp. Inert atmosphere,Store in freezer, under -20°C
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • color White to Off-White
  • FDA UNII OQW30I1332
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • HazardClass  :IRRITANT
  • Toxicity :LD50 in mice (mg/kg): 1000 orally, 60 i.v. (Brosnan)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P330-P501

2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Chemical Properties,Usage,Production

  • Chemical Properties Off-White Solid
  • Originator Vivalan,I.C.I. ,UK,1974
  • Uses Rac Viloxazine Hydrochloride is research useful chemical used as an antidepressant.
  • Manufacturing Process 2-Ethoxyphenol is first reacted with epichlorohydrin to give 1,2-epoxy-3-(o- ethoxyphenoxy)-propane.
    A mixture of crude (83%) 1,2-epoxy-3-(o-ethoxyphenoxy)propane (19.4 grams), 70.5 grams 2-aminoethyl hydrogen sulfate, 40.0 grams sodium hydroxide, 400 ml ethanol and 200 ml water is stirred at 60°C for 18 hours and is then evaporated to dryness. The residue is dissolved in 200 ml water and the mixture is extracted three times with 150 ml of diethyl ether each time. The combined extracts are dried over magnesium sulfate and evaporated to dryness, The crude product (21.5 grams) is dissolved in isopropanol (20 ml), 10.5 ml concentrated aqueous hydrochloric acid and 75 ml ethyl acetate are added and the mixture is cooled. The mixture is filtered and there is thus obtained as solid product 2-(o-ethoxyphenoxymethyl) morpholine hydrochloride, MP 179° to 182°C (8.6 grams; 38% yield based on total epoxide used), according to US Patent 3,712,890.
  • Therapeutic Function Psychotropic
  • Biological Activity Viloxazine (ICI 58,834) is an orally active serotonin norepinephrine modulating agent (SNMA) originally reported as a norepinephrine reuptake inhibitor (NRI) with antidepressant (ED10 from 0.3-1 mg/kg p.o. against reserpine-induced hypothermia in mice), while exhibiting less sedative efficacy (locomotor activity reduction ED10 from 3-10 mg/kg p.o. in mice) and no monoamine oxidase inhibitory potency. Viloxazine shows 5-HT2B antagonist and 5-HT2C agonist activity in vitro and increases extracellular 5-HT levels in the prefrontal cortex (PFC) in vivo, a brain area implicated in Attention deficit hyperactivity disorder (ADHD).
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Suppliers
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