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viloxazine

viloxazine Structure
viloxazine
  • CAS No.46817-91-8
  • Chemical Name:viloxazine
  • CBNumber:CB0911793
  • Molecular Formula:C13H19NO3
  • Formula Weight:237.29
  • MOL File:46817-91-8.mol
viloxazine Property
  • Melting point 176-179 °C
  • Boiling point 379.83°C (rough estimate)
  • Density 1.0942 (rough estimate)
  • refractive index 1.5000 (estimate)
  • pka pKa 8.1 (Uncertain)
  • form Oil
  • color Colorless to light yellow
  • FDA UNII 5I5Y2789ZF
  • ATC code N06AX09
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

viloxazine Chemical Properties,Usage,Production

  • Originator Vivalan,I.C.I. ,UK,1974
  • Uses Antidepressant.
  • Definition ChEBI: 2-[(2-ethoxyphenoxy)methyl]morpholine is an aromatic ether.
  • Manufacturing Process 2-Ethoxyphenol is first reacted with epichlorohydrin to give 1,2-epoxy-3-(o- ethoxyphenoxy)-propane.
    A mixture of crude (83%) 1,2-epoxy-3-(o-ethoxyphenoxy)propane (19.4 grams), 70.5 grams 2-aminoethyl hydrogen sulfate, 40.0 grams sodium hydroxide, 400 ml ethanol and 200 ml water is stirred at 60°C for 18 hours and is then evaporated to dryness. The residue is dissolved in 200 ml water and the mixture is extracted three times with 150 ml of diethyl ether each time. The combined extracts are dried over magnesium sulfate and evaporated to dryness, The crude product (21.5 grams) is dissolved in isopropanol (20 ml), 10.5 ml concentrated aqueous hydrochloric acid and 75 ml ethyl acetate are added and the mixture is cooled. The mixture is filtered and there is thus obtained as solid product 2-(o-ethoxyphenoxymethyl) morpholine hydrochloride, MP 179° to 182°C (8.6 grams; 38% yield based on total epoxide used), according to US Patent 3,712,890.
  • Therapeutic Function Psychotropic
viloxazine Preparation Products And Raw materials
Raw materials
Preparation Products
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viloxazine Spectrum
46817-91-8, viloxazineRelated Search:
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  • 46817-91-8
  • Metrifonate Impurity 2-d6(Metrifonate EP Impurity B-d6)(Dichlorvos-d6)
  • Morpholine, 2-[(2-ethoxyphenoxy)methyl]-
  • 2-[(2-Ethoxyphenoxy)methyl]morpholine
  • viloxazine

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