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Dimetotiazine

Dimetotiazine Property

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Dimetotiazine Chemical Properties,Usage,Production

Originator Migristene,Rhone Poulenc,France,1965
Uses Serotonin inhibitor.
Definition ChEBI: Dimetotiazine is a member of phenothiazines.
Manufacturing Process A solution of 3-dimethylsulfamoylphenthiazine (10 grams) in xylene (100 cc) is heated under reflux for 3 hours with sodium amide (1.5 grams). A solution of 1-dimethylamino-2-chloropropane (4.4 grams) in anhydrous xylene (30 cc) is then added and heating under reflux continued for 4 hours. After cooling the suspension obtained is agitated with water (50 cc) and ether (30 cc). The aqueous layer is separated and the basic products are extracted from the organic phase with 10% hydrochloric acid. The xylene layer is discarded and, after the combined acid solutions have been made alkaline with sodium carbonate, the base is extracted with chloroform. The chloroform solutions are then washed with water and dried over anhydrous potassium carbonate. After evaporation of the solvent under reduced pressure there is obtained a crude resinous base (9.7 grams).
On the addition of ethereal hydrogen chloride to a solution of the base in isopropanol and recrystallization from anhydrous ethanol of the salt formed, there is obtained 3-dimethylsulfamoyl-10-(2-dimethylaminopropyl) phenthiazine hydrochloride (2.1 grams), MP 214°C with decomposition. After dissolving the product in anhydrous ethanol and adding methanesulfonic acid there is obtained fonazine mesylate.

in vivo

Dimethothiazine (0.5-16 mg/kg; i.v.; single dosage) reduces decerebrate rigidity in cats^[2].

Animal Model:	Cats (decerebrate model; the carotid arteries were clamped and the mid-brain sectioned approximately between the colliculae)^[2]
Dosage:	0.5, 1, 2, 4, 8 and 16 mg/kg
Administration:	i.v.; single dosage
Result:	Reduced the discharge frequency of primary and secondary endings at 1-4 mg/kg. Reduced the sensitivity of the muscle spindle to stretch in preparations with intact ventral roots. Reduced the activity of the dynamic fusimotor fibres.

Dimetotiazine Preparation Products And Raw materials

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Dimetotiazine Spectrum

7456-24-8, DimetotiazineRelated Search:

抑制剂
医药原料
C20H29N3O5S3
化合物 FONAZINE
化合物 T31844
二甲替嗪
7456-24-8
Dimetotiazine USP/EP/BP
Dimethylsulfamido-3-(dimethylamino-2-propyl)-10-phenothiazine
Dimethodin
Brn 0941549
Bayer 1483
3-Dimethylsulfonamido 10-(2-dimethylaminopropyl)phenothiazine
13115-40-7 (Monomesylate)
N,N-Dimethyl-10-[2-(dimethylamino)propyl]-10H-phenothiazine-2-sulfonamide
Dimetothiazine
8599RP
Dimetiotazine
Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl- (6CI, 7CI, 8CI)
Fonazine
Dimethothiazine
Dimethiotazine
10H-Phenothiazine-2-sulfonamide, 10-[2-(dimethylamino)propyl]-N,N-dimethyl-
10-[2-(Dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide
10-(2-dimethylaminopropyl)-N,N-dimethyl-phenothiazine-2-sulfonamide: m ethanesulfonic acid
Dimetotiazine