Antazoline

Antazoline Property

Safety

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H335-H302-H315-H319-H312
Precautionary statements P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Antazoline Chemical Properties,Usage,Production

Chemical Properties White, odorless crystalline powder with bitter taste. Sparingly soluble in alcohol and water; practically insoluble in benzene and ether.
Originator Antistine HCl,Ciba,US,1948
Uses Antihistaminic.
Definition ChEBI: A member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug.
Manufacturing Process 15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline and 150 parts of alcohol are heated in an oil bath at 100° to 110°C. After distilling off the alcohol, the reaction mass is maintained at this temperature for a further 3 hours and then triturated with water and 10 parts of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether and the aqueous solution neutralized with dilute hydrochloric acid. By evaporating this solution and extracting the residue with alcohol there is obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C.
Therapeutic Function Antihistaminic
Clinical Use Antazoline is used for local application to the eye in allergic conjunctivitis.
Safety Profile Poison by ingestion, subcutaneous, and intraperitoneal routes. An eye irritant. When heated to decomposition it emits toxic fumes of NOx.

Antazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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Antazoline Spectrum

91-75-8, AntazolineRelated Search:

抑制剂
合成有机化合物配体
医药原料药
系列1
原料中间体-原料药
Imidazoline agonist; more potent than efaroxan in inducing insulin release from beta cells; H1 histamine receptor antagonist.
C17H20N3Cl
安他唑啉,10 MM DMSO 溶液
安他唑林盐酸盐
安他唑啉
N-苄基-N-(4,5-二氢-1H-咪唑-2-基甲基)苯胺
盐酸安太林
安他心
91-75-8
Antazoline, 10 mM in DMSO
nervous system,Inhibitor,H1 receptor antagonist,inhibit,Phenazoline,Antazoline,Histamine Receptor
Antazoline USP/EP/BP
Antazoline Hydrochloride Ph. Eur.
Antazoline & Antazoline Hydrochloride
N-benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)benzenamine
Antazoline (base and/or unspecified salts)
N-benzyl-N-(2-imidazolin-2-ylmethyl)aniline
ANTAZOLINE 0.5 H2SO4
ANTAZOLINE
BENZYL-(4,5-DIHYDRO-1H-IMIDAZOL-2-YLMETHYL)-PHENYL-AMINE 0.5 H2SO4
2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE 0.5 H2SO4
albalon-a
Sulfatreis
Sulfaperine
Risulfasens
Phenazoline
Orosulfan
Imidamine
Histostab
Demosulfan
Chemiopen
n-benzyl-n-(4,5-dihydro-1h-imidazol-2-ylmethyl)aniline
Ben-a-hist
Azalone
Avissul
Archisulfa
Antistine
Antistin
Antihistal
Antazolin
Antasten
Antastan
Analergine
Allergan A
5512-M
4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine
2-Phenyl-benzyl-amino-methylimidazolin
2-Imidazoline, 2-[(N-benzylanilino)methyl]-
2-[(N-Benzylanilino)methyl]-2-imidazoline
2-[(N-Benzylanilino)methyl]-2-imidazol
2-(N-Phenyl-N-benzylaminomethyl)imidazoline
1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-