Description
1,2,3-Trioctanoyl glycerol-
13C
3 is intended for use as an internal standard for the quantification of 1,2,3-trioctanoyl glycerol by GC- or LC-MS. 1,2,3-Trioctanoyl glycerol is a triacylglycerol that contains octanoic acid at the
sn-1,
sn-2, and
sn-3 positions. Dietary administration of 1,2,3-trioctanoyl glycerol increases hippocampal levels of the glycolytic metabolites glucose 6-phosphate, fructose 6-phosphate, and β-hydroxybutyrate and the seizure threshold in the 6 Hz psychomotor seizure test in mice. Formulations containing 1,2,3-trioctanoyl glycerol have been used in cosmetic products as thickening and skin-conditioning agents.
Uses
Tricaprilin-13C3 (Trioctanoin-13C3) is a 13C-labeled Tricaprilin (HY-B1804)[1]. Tricaprilin is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT)[1][2][3].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:
10.1177/1060028018797110[2] Tricaprylin
[3] Kwok MK, et al. Re-thinking Alzheimer's disease therapeutic targets using gene-based tests. EBioMedicine. 2018 Nov;37:461-470. DOI:
10.1016/j.ebiom.2018.10.001
