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CYTOCHALASIN J

CYTOCHALASIN J Structure
CYTOCHALASIN J
  • CAS No.53760-20-6
  • Chemical Name:CYTOCHALASIN J
  • CBNumber:CB2402529
  • Molecular Formula:C28H37NO4
  • Formula Weight:451.6
  • MOL File:53760-20-6.mol
CYTOCHALASIN J Property
  • Melting point 138°C (dec.)
  • Boiling point 679.5±55.0 °C(Predicted)
  • Density 1.20±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
  • form white lyophilisate
  • pka 13.03±0.70(Predicted)
  • color White
  • Stability Light Sensitive
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H310-H351-H330-H300
  • Precautionary statements P201-P202-P281-P308+P313-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501

CYTOCHALASIN J Chemical Properties,Usage,Production

  • Uses Cytochalasin J is a cell-permeable fungal toxin used in actin polymerization studies and cytological research.
  • Biological Activity cytochalasin j can alter mitotic spindle microtubule organization and kinetochore structure.the cytochalasins are cell-permeable fungal metabolites inhibiting actin polymerization, which can alter diverse processes including cell movement, growth, phagocytosis, degranulation, and secretion.
  • in vitro cytochalasin j was identified as a deacetylated analog of cytochalasin h that weakly inhibited actin assembly but significantly altered mitotic spindle microtubule organization and kinetochore structure [1]. in a previous study, cytochalasin j treatment of prometaphase cells reduced the number of kmts and the size and organization of the kinetochore lamina. moreover, in approximately 30% of cells treated with cytochalasin j, the failure of a small number of chromosomes to attach to spindle fibers could be documented. these chromosomes showed a significant change in the organization of the kinetochore laminae. light microscopic analyses of cells treated with cytochalasin j revealed loss of chromosome congression, with chromsomes usually located at the periphery of the spindle. cells treated with 10 microg/ml cytochalasin j for 10 min and released into tissue culture medium showed a resumption of chromosome motion within a few minutes, both during congression and anaphase [2].
  • storage +4°C
  • References [1] walling, e. a.,krafft, g.a. and ware, b.r. actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery. archives of biochemistry and biophysics 264(1), 321-332 (1988).
    [2] wrench, g. a. and snyder, j.a. cytochalasin j treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in ptk1 cells. cell motility and the cytoskeleton 36(2), 112-124 (1997).
CYTOCHALASIN J Preparation Products And Raw materials
Raw materials
Preparation Products
CYTOCHALASIN J Suppliers
Global(37)Suppliers
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    Aladdin Scientific
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CYTOCHALASIN J Spectrum
53760-20-6, CYTOCHALASIN JRelated Search:
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  • deacetylcytochalasin H
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  • CYTOCHALASIN J

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