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Hydrocortisone sodium phosphate

Hydrocortisone sodium phosphate Structure
Hydrocortisone sodium phosphate
  • CAS No.6000-74-4
  • Chemical Name:Hydrocortisone sodium phosphate
  • CBNumber:CB2397209
  • Molecular Formula:C21H29O8P.2Na
  • Formula Weight:486.41
  • MOL File:6000-74-4.mol
Hydrocortisone sodium phosphate Property
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H373-H312-H332-H361
  • Precautionary statements P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P260-P314-P501-P201-P202-P281-P308+P313-P405-P501

Hydrocortisone sodium phosphate Chemical Properties,Usage,Production

  • Originator Corphos,Tilden Yates,US,1959
  • Uses Hydrocortisone Sodium Phosphate is the sodium phosphate salt of the corticosteroid Hydrocortisone (H714615).
  • Definition ChEBI: An organic sodium salt that is the disodium salt of cortisol phosphate.
  • Manufacturing Process 21-iodo-11β:17α-dihydroxypregn-4-ene-3,20-dione (5.0 g) in pure acetonitrile (125 ml) was mixed with a solution of 90% phosphoric acid (2.5 ml) and triethylamine (7.5 ml) in acetonitrile (125 ml) and boiled under reflux for 4 hours. The solvent was removed in vacuo and the residue, dissolved in ethanol (20 ml) and water (80 ml), was passed down a column of Zeo-Karb 225 (H+form) (60 g) made up in 20% alcohol. Elution was continued with 20% alcohol (50 ml), 50% alcohol (50 ml) and alcohol (150 ml). The eluate was at first cloudy, but by the end of the elution it was clear and nonacid.
    The eluate was titrated to pH 7 with 0.972N NaOH (63 ml). Removal of solvent left a gum, which was boiled with methanol (400 ml) for 20 minutes. The solid insoluble inorganic phosphate was filtered off and washed with methanol (200 ml). The slightly cloudy filtrate was filtered again, and evaporated to dryness in vacuo. The residual gum dissolved readily in water (40 ml) and on addition of acetone (600 ml) to the solution a mixture of sodium salts of hydrocortisone 21-phosphate separated as a white solid. This was collected after 2 days, washed with acetone and dried at 100°C/0.l mm/2 hr to constant weight. Yield 4.45 g.
  • brand name Hydrocortone (Merck).
  • Therapeutic Function Glucocorticoid
Hydrocortisone sodium phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
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Hydrocortisone sodium phosphate Spectrum
6000-74-4, Hydrocortisone sodium phosphateRelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroid and Hormone
  • Steroids
  • 抑制剂
  • 试剂
  • 威德利现货找张军
  • 化学试剂
  • 原料药
  • 医用原料
  • 医药原料
  • 医药原料
  • 医用原料
  • 医药原料药
  • C21H29Na2O8P
  • C21H29O8P2Na
  • C21H29O8PNa2
  • 磷酸氢化可的松二钠盐
  • 氢化可的松磷酸钠
  • 化合物 HYDROCORTISONE PHOSPHATE SODIUM
  • 6000-74-4
  • Hydrocortisone Phosphate Disodium Salt
  • Hydrocortisone Sodium Phosphate
  • 4-PREGNEN-11β, 17, 21-TRIOL-3, 20-DIONE-21-PHOSPHATE SODIUM SALT
  • Hydrocortisone Sodium Phosphate RS
  • Hydrocortisone sodium phosphate USP/EP/BP
  • HYDROCORTISONE 21-PHOSPHATE SODIUM SALT
  • Hydrocortisone phosphate sodium
  • Coriphate
  • 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(phosphoric acid disodium) salt
  • (11b)-11,17-Dihydroxy-21-(phosphonooxy)pregn-4-ene-3,20-dione disodium salt
  • Sodium cortisol 21-phosphate
  • Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11β)-
  • Physiocortison
  • Hydrocortone phosphate
  • Hydrocortisone disodium phosphate
  • Hydrocortisone 21-sodium phosphate
  • Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11beta)-
  • hydrocortisone sodium phosphate usp
  • SODIUM HYDROCORTISONE-21-PHOSPHATE
  • CORTISOL SODIUM PHOSPHATE
  • Hydrocortisone 21-phosphate disodium salt
  • Hydrocortisone 21-phosphate disodium
  • Hydrocortisone 21-disodium salt
  • Hydrocortisone 21-disodium phosphate
  • Efcortesol
  • Disodium hydrocortisone 21-phosphate
  • Cortisol, 21-(dihydrogen phosphate), disodium salt (7CI, 8CI)
  • Cortisol 21-phosphate disodium salt (6CI)
  • 4-PREGNEN-11-BETA, 17,21-TRIOL-3,20-DIONE-21-PHOSPHATE SODIUM SALT

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