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(R)-5,7-difluorochroman-4-ol

(R)-5,7-difluorochroman-4-ol Structure
(R)-5,7-difluorochroman-4-ol
  • CAS No.1270294-05-7
  • Chemical Name:(R)-5,7-difluorochroman-4-ol
  • CBNumber:CB23354564
  • Molecular Formula:C9H8F2O2
  • Formula Weight:186.16
  • MOL File:1270294-05-7.mol
(R)-5,7-difluorochroman-4-ol Property
  • Boiling point 228.4±40.0 °C(Predicted)
  • Density 1.402±0.06 g/cm3(Predicted)
  • pka 13.09±0.20(Predicted)
  • InChI InChI=1S/C9H8F2O2/c10-5-3-6(11)9-7(12)1-2-13-8(9)4-5/h3-4,7,12H,1-2H2/t7-/m1/s1
  • InChIKey HGTYMLFMXKYIQW-SSDOTTSWSA-N
  • SMILES C1OC2=CC(F)=CC(F)=C2[C@H](O)C1
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

(R)-5,7-difluorochroman-4-ol Chemical Properties,Usage,Production

  • Uses (R)-5,7-difluorochroman-4-ol is an important intermediate in the synthesis of tegoprazan[1].
  • Production Methods Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol, where ketoreductase is one or combination of two or more of short-chain dehydrogenases/reductases family (SDR), medium-chain dehydrogenases/reductase (MDR) or aldo-Keto reductase (AKR)[1].
  • References [1]PAN X, et al. "Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate, and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol.", CN202210486605.0. 2022.
(R)-5,7-difluorochroman-4-ol Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-5,7-difluorochroman-4-ol Suppliers
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(R)-5,7-difluorochroman-4-ol Spectrum
1270294-05-7, (R)-5,7-difluorochroman-4-olRelated Search:
  • API
  • 系列1
  • 抑制剂
  • 化学试剂
  • 化工试剂
  • 化工中间体-化工原料
  • 医药原料
  • 杂质对照品
  • 特戈拉赞
  • 新产品
  • 特戈拉赞中间体二
  • 替戈拉生杂质C
  • 化合物 (R)-5,7-DIFLUOROCHROMAN-4-OL
  • 特戈拉赞杂质8
  • 特戈拉赞侧链
  • 特戈拉赞中间体2
  • 替戈拉生中间体
  • 特戈拉赞杂质6
  • (R)-5,7-二氟色满-4-醇
  • 替戈拉生杂质11
  • 特戈拉赞中间体
  • LXI-15028-03
  • (R)-5,7-二氟苯并吡喃-4-醇
  • (R)-5,7-二氟四氢苯并吡喃-4-醇
  • R-5,7-二氟苯并二氢吡喃-4-醇
  • 1270294-05-7
  • Tigora produced impurity 11
  • Tegoprazan Impurity
  • Tegoprazan ImpuritiesC
  • Tegoprazan side chain
  • (R)-5, 7-difluorobenzopyrane-4-ol
  • [2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine]
  • (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol
  • R-5,7-difluorobenzo dihydropyran-4-ol
  • Tegoprazan Impurity 11
  • 2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-

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