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Sulfamethazine sodium salt

CAS No.1981-58-4
Chemical Name:Sulfamethazine sodium salt
CBNumber:CB2284761
Molecular Formula:C12H15N4NaO2S
Formula Weight:302.33
MOL File:1981-58-4.mol

Sulfamethazine sodium salt Property

Melting point >288°C (dec.)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: soluble50mg/mL
form powder
color white to off-white
Water Solubility H2O: soluble 50mg/mL
Merck 14,8915
Stability Hygroscopic
CAS DataBase Reference 1981-58-4
FDA UNII 7Z13P9Q95C
EPA Substance Registry System Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-, monosodium salt (1981-58-4)
UNSPSC Code 51284910
NACRES NA.85

Safety

Hazard Codes :Xn
Risk Statements :22
Safety Statements :36
WGK Germany :3
RTECS :WO9300000
HS Code :2933.59.8000

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P264-P270-P301+P312-P501

Sulfamethazine sodium salt Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: S5637
Product name : Sulfamethazine sodium salt
Purity: ≥98%
Packaging: 25G
Price: ₹2901.1
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: S5637
Product name : Sulfamethazine sodium salt
Purity: ≥98%
Packaging: 100G
Price: ₹4037.73
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: S0583
Product name : Sulfamethazine Sodium Salt
Purity:
Packaging: 25G
Price: ₹2000
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: S0583
Product name : Sulfamethazine Sodium Salt
Purity:
Packaging: 500G
Price: ₹6900
Updated: 2022/05/26
Buy: Buy

Sulfamethazine sodium salt Chemical Properties,Usage,Production

Uses Antibacterial;Inhibitor of folic acid synthesis
Biological Activity Sulfamethazine is an antimicrobial sulfur drug th at blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

in vivo

Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC_0->∞, significantly increases t_1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01^[1].

Animal Model:	19 healthy female pigs (6-week-old, 4.5-6.2 kg)^[1]
Dosage:	80 mg/kg
Administration:	Intravenous injection (Pharmacokinetic study)
Result:	The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC_0->∞ were significantly decreased and t_1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.

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