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PAROMOMYCIN SULFATE

CAS No.1263-89-4
Chemical Name:PAROMOMYCIN SULFATE
CBNumber:CB2278832
Molecular Formula:C23H47N5O18S
Formula Weight:713.71
MOL File:1263-89-4.mol

PAROMOMYCIN SULFATE Property

Melting point 145 °C (decomp)
alpha D25 +50.5° (c = 1.5 in water pH 6)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility H₂O: 50 mg/mL store stock solution at 2-8°C. Stable at 37°C for 5 days.
form powder
color White to Off-White
Water Solubility Soluble in water
Merck 14,7041
BRN 5715182
Stability Hygroscopic
InChIKey LJRDOKAZOAKLDU-UDXJMMFXSA-N
CAS DataBase Reference 1263-89-4
FDA UNII 845NU6GJPS
NCI Drug Dictionary Humatin
EPA Substance Registry System Paromomycin sulfate (1263-89-4)
UNSPSC Code 12352200
NACRES NA.72

Safety

Hazard Codes :Xi
Risk Statements :23/24/25-36/38-39/23/24/25-61-36/37/38
Safety Statements :26-36/37-45-38-36
WGK Germany :2
RTECS :WK2320000
HS Code :2941901010
Toxicity :LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a

PAROMOMYCIN SULFATE Price More Price(13)

Brand: Sigma-Aldrich(India)
Product number: P9297
Product name : Paromomycin sulfate salt
Purity: ≥98% (TLC)
Packaging: 1G
Price: ₹7350.18
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: P9297
Product name : Paromomycin sulfate salt
Purity: ≥98% (TLC)
Packaging: 5G
Price: ₹14418.9
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: PHR1496
Product name : Paromomycin Sulfate
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500MG
Price: ₹9103.83
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: P9297
Product name : Paromomycin sulfate salt
Purity: ≥98% (TLC)
Packaging: 25G
Price: ₹49459.43
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: P8692
Product name : Paromomycin sulfate salt
Purity: suitable for plant cell culture, BioReagent
Packaging: 5G
Price: ₹18034.45
Updated: 2022/06/14
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PAROMOMYCIN SULFATE Chemical Properties,Usage,Production

Description Paromomycin was found in the culture broth of Streptomyces rimosus forma paromomycinus by Parke Davis & Co. in 1959. In the same year it was found in the culture broth of S. Crestomyceticus by Farmitalia and named amminosidin. Paromomycin is related structurally to neomycin, but it has a hydroxyl group at the 6 position, whereas neomycin has an amino group. Its antibacterial activity is weaker than that of neomycin, but its toxicity is much less. Paromomycin is used by intramuscular injection for therapy of respiratory, urinary, and surgical infections and by oral administration to treat dysentery and salmonellosis.
Chemical Properties PAROMOMYCIN SULFATE is White to Off-White Solid
Uses PAROMOMYCIN SULFATE is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed addit ive in turkey poults experimentally infected with Histomonas meleagridis.
Uses polymeric nonionic detergent
Uses antibacterial, antiamebic
Definition ChEBI: An aminoglycoside sulfate salt resulting from the treatment of paromomycin with sulfuric acid. A broad-spectrum antibiotic, it is used for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoa infections. It is also used as a therapeutic against visceral leishmaniasis.
brand name Humatin (King); Humatin (Parke- Davis).
General Description Chemical structure: aminoglycoside
Biochem/physiol Actions Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
Clinical Use The isolation of paromomycin (Humatin) was reported in1956 from a fermentation with a Streptomyces sp. (PD04998), a strain said to resemble S. rimosus very closely.The parent organism had been obtained from soil samplescollected in Colombia. Paromomycin, however, moreclosely resembles neomycin and streptomycin in antibioticactivity than it does oxytetracycline, the antibiotic obtainedfrom S. rimosus.
Paromomycin has broad-spectrum antibacterial activityand has been used for the treatment of GI infections causedby Salmonella and Shigella spp., and enteropathogenic E.coli. Currently, however, its use is restricted largely to thetreatment of intestinal amebiasis. Paromomycin is soluble inwater and stable to heat over a wide pH range.
Safety Profile Poison by intravenous,subcutaneous, and intramuscular routes. Mildly toxic byingestion. Mutation data reported. When heated to decomposition it emits very toxic fumesof SOx and NOx.
Purification Methods Purify it by dissolving it in H2O (0.5g/10mL) and adding excess EtOH, filter or collect and wash with EtOH, then Et2O by centrifugation, and dry it in vacuo. An aqueous solution is stable at 37o for a week but longer at 0-5o. The free base [7542-37-2] is a white amorphous powder which should be stored under N2 because it is strongly basic and can absorb CO2 from the atmosphere. It is soluble in MeOH (less soluble in EtOH) and has [] D 25 +65o (c 1.5, MeOH). It is an antimicrobial against Gram +ve and Gram –ve bacteria and is antiamoebic. It inhibits initiation and peptide elongation during protein synthesis. [Haskell et al. J Am Chem Soc 8 1 , 3480, 3482 1959, Hichens & Rinehart J Am Chem Soc 85 1547 1963, Beilstein 18 III/IV 7534.]