ChemicalBook > CAS DataBase List > ABBV-075

ABBV-075

ABBV-075 Structure
ABBV-075
  • CAS No.1445993-26-9
  • Chemical Name:ABBV-075
  • CBNumber:CB22738567
  • Molecular Formula:C22H19F2N3O4S
  • Formula Weight:459.47
  • MOL File:1445993-26-9.mol
ABBV-075 Property
  • Boiling point 608.9±65.0 °C(Predicted)
  • Density 1.465±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO:60.0(Max Conc. mg/mL);130.59(Max Conc. mM)
  • form A crystalline solid
  • pka 8.37±0.10(Predicted)
  • color White to off-white
  • FDA UNII VR86R11J7J
  • NCI Drug Dictionary mivebresib
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H320-H335
  • Precautionary statements P264-P270-P301+P312-P330

ABBV-075 Chemical Properties,Usage,Production

  • Uses ABBV 075-d5 is a deuterium labelled ABBV 075 (A215280), which is used for selective inhibition of the BD2 bromodomain of bromodomain and extra-??terminal proteins in prostate cancer.
  • Biological Activity Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. Binds to the bromodomain of BRD2/4/T with similar affinity (Ki values between 1-2.2 nM) with high selectivity. Low potency against BRD3 (Ki=12.2 nM) and moderate activity against CREBBP (Ki=87 μM). It can effectively trigger apoptosis in a variety of tumor cells.
  • in vitro

    ABBV-075 has potent and potent single-agent activity in a variety of cancer cell lines (from solid tumors, leukemias and lymphomas) in cell viability assays. It is capable of disrupting cell cycle control, leading to G1 arrest, further senescence, inhibition of tumor formation, induction of apoptosis, and possibly targeting the tumor microenvironment to further provide better efficacy.

  • in vivo In mouse models laterally xenografted with non-small cell and small cell lung cancer, pancreatic cancer, breast cancer, prostate cancer, head and neck cancer, multiple lymphomas, diffuse giant B-cell lymphoma, and leukemia, ABBV -075 has equal or better efficacy than other standard care agents.
  • target
    TargetValue
    BRD2
    BRD4
    BRD-T
ABBV-075 Preparation Products And Raw materials
Raw materials
Preparation Products
ABBV-075 Suppliers
Global(110)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    CR Corporation Limited
  • Tel： +8613062833949
  • Email：fred.wen@crcorporation.cn
  • Country：China
  • ProdList：8647
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
ABBV-075 Spectrum
1445993-26-9, ABBV-075Related Search:
  • 抑制剂
  • 生物试剂
  • 合成有机化合物配体
  • 活性小分子库
  • 细胞生物学试剂
  • 2115742-03-0
  • 米维布塞,10 MM DMSO 溶液
  • N-(4-(2,4-二氟苯氧基)-3-(6-甲基-7-氧代-6,7-二氢-1H-吡咯并[2,3-C]吡啶-4-基)苯基)乙磺酰胺
  • BET家族抑制剂(MIVEBRESIB)
  • 米维布塞
  • 1445993-26-9
  • Mivebresib, 10 mM in DMSO
  • Terbufos Impurity 12 (Vamidothion)
  • 5100
  • Mivebresib
  • Ethanesulfonamide, N-[4-(2,4-difluorophenoxy)-3-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-
  • Mivibus
  • CS-2464
  • Mivebresib (ABBV075, ABBV-075, ABBV 075)
  • CS-2213
  • ABBV-075; ABBV075; ABBV 075
  • Mivebresib (ABBV-075 )
  • ABBV-075
  • N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide

Home

My