ChemicalBook > CAS DataBase List > FLLL31

FLLL31

FLLL31 Structure
FLLL31
  • CAS No.52328-97-9
  • Chemical Name:FLLL31
  • CBNumber:CB22731058
  • Molecular Formula:C25H28O6
  • Formula Weight:424.49
  • MOL File:52328-97-9.mol
FLLL31 Property
  • Boiling point 594.5±50.0 °C(Predicted)
  • Density 1.140±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: ≥10mg/mL
  • form powder
  • color yellow
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H410
  • Precautionary statements P273-P501
FLLL31 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: F9057
  • Product name : FLLL31
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹12680
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: F9057
  • Product name : FLLL31
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹51010
  • Updated: 2022/06/14
  • Buy: Buy

FLLL31 Chemical Properties,Usage,Production

  • Uses Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects[1][2].
  • Biological Activity Tetramethylcurcumin (FLLL31) is derived from curcumin and specifically inhibits phosphorylation of STAT3 by selectively binding to Janus kinase 2 and the STAT3 Src homology 2 domain. Tetramethylcurcumin has anti-inflammatory and anticancer effects.
  • in vitro

    Tetramethylcurcumin (FLLL31; 2.5 and 5 μM; for 24 hours) downregulas STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells.
    Tetramethylcurcumin inhibits cell viability , cell invasion. Tetramethylcurcumin is an effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.

  • target

    STAT3

  • IC 50 STAT3
  • References [1] Lin L, et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res.?2010 Mar 15;70(6):2445-54. DOI:10.1158/0008-5472.CAN-09-2468
    [2] Yuan S, et al. FLLL31, a derivative of curcumin, attenuates airway inflammation in a multi-allergen challenged mouse model. Int Immunopharmacol.?2014 Jul;21(1):128-36. DOI:10.1016/j.intimp.2014.04.020
FLLL31 Preparation Products And Raw materials
Raw materials
Preparation Products
FLLL31 Suppliers
Global(77)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier：
    Mensura Group Limited
  • Tel： +8618109034517
  • Email：1058503172@qq.com
  • Country：China
  • ProdList：2900
  • Advantage：58
FLLL31 Spectrum
52328-97-9, FLLL31Related Search:
  • 抑制剂
  • 中药标准品，对照品
  • 标准品 -中药标准品
  • 对照品-中药对照品
  • 对照品
  • 植物提取物
  • 四甲基姜黄素,10 MM DMSO 溶液
  • 四甲基姜黄素/酚类
  • 四甲基姜黄素(FLLL31)
  • (1E,6E)-1,7-双(3,4-二甲氧基苯基)-4,4-二甲基庚-1,6-二烯-3,5-二酮
  • 52328-97-9
  • Tetramethylcurcumin, 10 mM in DMSO
  • Tetramethylcurcumin（FLLL31）
  • pancreatic,FLLL-31,domain,FLLL 31,Apoptosis,Inhibitor,STAT,Tetramethylcurcumin,cancer,kinase,Curcumin,Janus,Src,anti-inflammatory,FLLL31,breast,inhibit,homology-2
  • (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione
  • FLLL31 >=98% (HPLC)
  • 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4,4-dimethyl-, (1E,6E)-
  • FLLL31;FLLL-31;FLLL 31
  • (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione
  • (E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione
  • Tetramethylcurcumin
  • FLLL31

Home

My