ChemicalBook CAS DataBase List 52328-97-9

52328-97-9

Name	FLLL31
CAS	52328-97-9
Molecular Formula	C25H28O6
MDL Number	MFCD19443859
Molecular Weight	424.49
MOL File	52328-97-9.mol

Chemical Properties

Boiling point	594.5±50.0 °C(Predicted)
density	1.140±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥10mg/mL
form	powder
color	yellow
InChI	1S/C25H28O6/c1-25(2,23(26)13-9-17-7-11-19(28-3)21(15-17)30-5)24(27)14-10-18-8-12-20(29-4)22(16-18)31-6/h7-16H,1-6H3/b13-9+,14-10+
InChIKey	VMMZAMVBGQWOHT-UTLPMFLDSA-N
SMILES	COc1ccc(\C=C\C(=O)C(C)(C)C(=O)\C=C\c2ccc(OC)c(OC)c2)cc1OC

Safety Data

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H410
Precautionary statements	P273-P501
WGK Germany	3
Storage Class	11 - Combustible Solids
Hazard Classifications	Aquatic Chronic 4

Hazard Information

Uses

Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects[1][2].

Biological Activity

Tetramethylcurcumin (FLLL31) is derived from curcumin and specifically inhibits phosphorylation of STAT3 by selectively binding to Janus kinase 2 and the STAT3 Src homology 2 domain. Tetramethylcurcumin has anti-inflammatory and anticancer effects.

in vitro

Tetramethylcurcumin (FLLL31; 2.5 and 5 μM; for 24 hours) downregulas STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells.
Tetramethylcurcumin inhibits cell viability , cell invasion. Tetramethylcurcumin is an effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.

target

STAT3

IC 50

STAT3

storage

Store at -20°C

References

[1] Lin L, et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res.?2010 Mar 15;70(6):2445-54. DOI:10.1158/0008-5472.CAN-09-2468
[2] Yuan S, et al. FLLL31, a derivative of curcumin, attenuates airway inflammation in a multi-allergen challenged mouse model. Int Immunopharmacol.?2014 Jul;21(1):128-36. DOI:10.1016/j.intimp.2014.04.020

Spectrum Detail

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