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Isradipine

Isradipine Structure
Isradipine
  • CAS No.75695-93-1
  • Chemical Name:Isradipine
  • CBNumber:CB2268682
  • Molecular Formula:C19H21N3O5
  • Formula Weight:371.39
  • MOL File:75695-93-1.mol
Isradipine Property
  • Melting point 166-1680C
  • Boiling point 501.9±60.0 °C(Predicted)
  • Density 1.249±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: ~26 mg/mL
  • form solid
  • pka 2.56±0.70(Predicted)
  • color yellow
  • Merck 14,5240
  • BCS Class 2/4
  • Stability Stable for 2 years from date of purchsae as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
  • InChIKey HMJIYCCIJYRONP-UHFFFAOYSA-N
  • CAS DataBase Reference 75695-93-1(CAS DataBase Reference)
  • FDA UNII YO1UK1S598
  • ATC code C08CA03
  • NIST Chemistry Reference Isradipine(75695-93-1)
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
  • HS Code  :2934990002
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H413
  • Precautionary statements P501-P273
Isradipine Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: I6658
  • Product name : Isradipine
  • Purity: ≥98% (HPLC), solid
  • Packaging: 5MG
  • Price: ₹17406.6
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: I6658
  • Product name : Isradipine
  • Purity: ≥98% (HPLC), solid
  • Packaging: 25MG
  • Price: ₹62785
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 5.08507
  • Product name : Isradipine - CAS 75695-93-1 - Calbiochem
  • Purity: A voltage gated calcium channel gating inhibitor of the dihydropyridine class.
  • Packaging: 10MG
  • Price: ₹12940
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: I0876
  • Product name : Isradipine
  • Purity: 
  • Packaging: 25MG
  • Price: ₹11600
  • Updated: 2022/05/26
  • Buy: Buy

Isradipine Chemical Properties,Usage,Production

  • Description Isradipine is a long-acting calcium blocker effective in the treatment of essential hypertension. The advantages of isradipine as compared with other dihydropyridine calcium antagonists include a "gentle" onset and fewer contraindications. It can be taken by patients with diabetes mellitus, chronic obstructive airway diseases, gout, congestive heart failure or ischemic heart disease.
  • Chemical Properties Yellow Solid
  • Originator Sandoz (Switzerland)
  • Uses nonsedating H1-antihistamine
  • Uses Dihydropyridine calcium channel blocker. Antihypertensive; antianginal
  • Uses Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.
  • Definition ChEBI: Isradipine is an isopropyl ester, a methyl ester, a dihydropyridine and a benzoxadiazole.
  • brand name Dynacirc (Reliant);Prescal.
  • General Description Isradipine, 4-(4-benzofuranazyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester (DynaCirc), is another second-generationdihydropyridine-type channel blocker. This drug, like theother second-generation analogs, is more selective for vascularsmooth muscle than for myocardial tissue. It is effectivein the treatment of stable angina, reducing the frequencyof anginal attacks and the need to use nitroglycerin.
  • Biological Activity Potent and selective L-type voltage-gated Ca 2+ channel blocker. EC 50 and pA 2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca 2+ -induced contractions of rabbit aorta respectively; EC 25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action.
  • Biochem/physiol Actions L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.
  • storage Room temperature
  • References 1) Bracht et al. (2001), Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia; J. Hyperten., 19 899 2) Chandra et al. (1999), Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia ; Pharmacology, 58 292 3) Merck 14:5240
Isradipine Preparation Products And Raw materials
Raw materials
Preparation Products
Isradipine Suppliers
Global(294)Suppliers
  • Supplier：
    Xiamen AmoyChem Co., Ltd
  • Tel：+86-86-5926051114<br/>+8615060885618
  • Email：sales@amoychem.com
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    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
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  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：marketing@targetmol.com
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  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
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  • Supplier：
    AFINE CHEMICALS LIMITED
  • Tel：+86-0571-85134551
  • Email：sales@afinechem.com
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  • Supplier：
    Finetech Industry Limited
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  • Email：info@finetechnology-ind.com
  • Country：China
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Isradipine Spectrum
75695-93-1, IsradipineRelated Search:
  • API
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Calcium channel
  • Ion Channels
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  • C19H15N3O5D6
  • 75695-63-1
  • 75696-93-1
  • 伊拉地平,10 MM DMSO 溶液
  • ISRADIPINE,L-TYPE CA2+ CHANNEL BLOCKER
  • 伊拉地平/A1A
  • 3-异丙基5-甲基 4-(苯并[C][1,2,5]恶二唑-4-基)-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸盐
  • 依拉地平 USP标准品
  • 伊拉地平 EP标准品
  • 依拉地平,伊拉地平
  • 伊拉地平 ISRADIPINE
  • 伊沙地平
  • 伊拉地平溶液,100PPM
  • 4-(4-苯并呋咱基)-2,6-二甲基-1,4-二氢-3,5-吡啶二羧酸甲酯1-甲基乙酯
  • 伊拉地平
  • 地拉平
  • 导脉顺
  • 75695-93-1
  • Isradipine, 10 mM in DMSO
  • Isradipine, L-type Ca2+ channel blocker
  • Isradipine in methanol
  • Isopropyl methyl(±)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Isradipine (1354207)
  • 4-(4-BChemicalbookenzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic[chemicalname]acidmethyl1-methylethylester
  • IsradipineQ: What is Isradipine Q: What is the CAS Number of Isradipine Q: What is the storage condition of Isradipine Q: What are the applications of Isradipine
  • Isradipine (PN 200-110)
  • Isradipine USP/EP/BP
  • Isopropyl Methyl 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Isopropyl Methyl 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimet
  • 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Isopropyl Methyl Ester
  • 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester
  • Isradipine CRS
  • Isradipine&gt
  • Isradipine Solution, 100ppm
  • PN 200-110;DYNACIRC; LOMIR; PRESCAL; DYNACIRC CR;
  • Dynacirc CR
  • (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester
  • CS-139

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