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Ipsapirone

Ipsapirone Structure
Ipsapirone
  • CAS No.95847-70-4
  • Chemical Name:Ipsapirone
  • CBNumber:CB2254702
  • Molecular Formula:C19H23N5O3S
  • Formula Weight:401.48
  • MOL File:95847-70-4.mol
Ipsapirone Property
  • Melting point 137-138°
  • Boiling point 629.8±65.0 °C(Predicted)
  • Density 1.345±0.06 g/cm3(Predicted)
  • storage temp. Store at RT
  • solubility Soluble to 10 mM in DMSO
  • form Powder
  • pka 7.69±0.10(Predicted)
  • color White to off-white
  • FDA UNII 6J9B11MN0K
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Ipsapirone Chemical Properties,Usage,Production

  • Uses Ipsapirone is a selective SR-1A agonist.
  • Uses Anti-anxiety agent .
  • Definition ChEBI: 1,1-dioxo-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzothiazol-3-one is a N-arylpiperazine.
  • Biological Activity Selective 5-HT 1A receptor agonist (K i = 10 nM). Anxiolytic in vivo .
  • in vivo

    Ipsapirone inhibits induced by 8-OH-DPAT and 5-methoxydimethyltryptamine (agonists of 5-HT1A receptors) behavioural effects (flat body posture and forepaw treading) in normal and reserpinized rats[1].
    Ipsapirone (2.5-80 mg/kg), given alone to rats induces a slight flattening of body posture (~ 1 point at the highest dose) and a mild hind limb abduction observed at doses 2.5-80 mg/kg. Ipsapirone given alone at low doses (2.5-10 mg/kg i.p.) does not significantly change the body temperature in rats and mice, but decreased it in both those species at high doses (35 mg/kg i.p.) by ca. 2-2.5℃[1].

    Animal Model:Male Albino-Swiss mice (18-24 g) and male Wistar rats (160-200 g)[1].
    Dosage:5 and 10 mg/kg.
    Administration:IP 30 min before 8-OH-DPAT and 5-MeODMT injections.
    Result:Behavioural responses (flat body posture, forepaw treading) to 8-OH-DPAT (5 mg/kg s.c.) in rats were antagonized by Ipsapirone (5 and 10 mg/kg i.p.).
  • IC 50 5-HT1A Receptor
  • storage Room temperature
Ipsapirone Preparation Products And Raw materials
Raw materials
Preparation Products
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Ipsapirone Spectrum
95847-70-4, IpsapironeRelated Search:
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  • 95847-70-4
  • Ipsapirone, 10 mM in DMSO
  • 1,2-Benzisothiazol-3(2H)-one, 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, 1,1-dioxide
  • Benzeneethanamine,5-chloro-α-methyl-
  • 2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide
  • Isapirone
  • 1,2-benzisothiazol-3(2h)-one,2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-,1,
  • 2-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-1,2-BENZISOTHIAZOL-3(2H)-ONE-1,1-DIOXIDE
  • IPSAPIRONE

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