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OSU-03012

OSU-03012 Structure
OSU-03012
  • CAS No.742112-33-0
  • Chemical Name:OSU-03012
  • CBNumber:CB22501006
  • Molecular Formula:C26H19F3N4O
  • Formula Weight:460.45
  • MOL File:742112-33-0.mol
OSU-03012 Property
  • storage temp. Store at -20°C
  • solubility ≥23 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
  • form solid
  • color White to off-white
  • CAS DataBase Reference 742112-33-0
  • FDA UNII EX3O2Q61UV
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

OSU-03012 Chemical Properties,Usage,Production

  • Description Cyclooxygenase-2 (COX-2) appears to play a significant role in the development and progression of cancer and COX-2 inhibitors such as celecoxib exhibit anti-cancer activity. OSU03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway. It has an IC50 value of 5 μM for inhibition of 3-phosphoinositide-dependent kinase-1, and therefore Akt activation, with no measurable COX-2 inhibition up to 50 μM. OSU03012 is a potent inhibitor of tumor cell growth with an average inhibitory concentration of 1.1 μM across a panel of 60 cancer cell lines. It does not inhibit signal transduction through the mitogen-activated protein kinase (MAPK) pathway. OSU03012 induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.
  • Uses OSU 03012 is a PDK1 inhibitor and inducer of caspase and p53-independent apoptosis, also used in the development of anticancer agents by modification of novel immunosuppressant FTY720 and PDK1 inhibitor OSU-03012, compound for treating Alzheimers diseases.
  • Definition ChEBI: A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.
  • storage Store at -20°C
  • References [1] zhu j1, huang jw, tseng ph, yang yt, fowble j, shiau cw, shaw yj, kulp sk, chen cs. from the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. cancer res. 2004 jun 15;64(12):4309-18.
    [2] lee tx1, packer md, huang j, akhmametyeva em, kulp sk, chen cs, giovannini m, jacob a, welling db, chang ls. growth inhibitory and anti-tumour activities of osu-03012, a novel pdk-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells. eur j cancer. 2009 jun;45(9):1709-20.
OSU-03012 Preparation Products And Raw materials
Raw materials
Preparation Products
OSU-03012 Suppliers
Global(138)Suppliers
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OSU-03012 Spectrum
742112-33-0, OSU-03012Related Search:
  • PI3K
  • mTOR
  • Akt
  • Inhibitor of phosphoinositide-dependent kinase-1.
  • Inhibitors
  • 信号转导通路激酶抑制剂
  • 医用原料
  • 抑制剂
  • 合成有机化合物配体
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • C26H19F3N4O
  • OSU-03012 (AR-12) |CAS 742112-33-0
  • 化合物OSU-03012,10 MM DMSO 溶液
  • OSU-03012 抑制剂
  • OSU-03012 (AR-12),PDPK1(PDK1)抑制剂
  • 2-氨基-N-[4-[5-(2-菲基)-3-(三氟甲基)-1H-吡唑-1-基]苯基]乙酰胺
  • 742112-33-0
  • Osu03012, 10 mM in DMSO
  • PDK1 inhibitor AR-12
  • Osu-03012|||Osu 03012|||AR-12
  • AR-12
  • OSU-03012 USP/EP/BP
  • Acetamide, 2-amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-
  • N/AAR-12; OSU03012; OSU 03012
  • CS-1848
  • OSU-03012 (AR-12);N/AAR-12; OSU03012; OSU 03012
  • 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide
  • OSU-03012
  • N/AAR-12
  • 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide OSU-03012
  • 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide
  • OSU-03012 (AR-12)
  • OSU-03012, >=98%

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