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BX-912

BX-912 Structure
BX-912
  • CAS No.702674-56-4
  • Chemical Name:BX-912
  • CBNumber:CB92454082
  • Molecular Formula:C20H23BrN8O
  • Formula Weight:471.35
  • MOL File:702674-56-4.mol
BX-912 Property
  • Density 1.596
  • storage temp. -20°C
  • solubility ≥23.55 mg/mL in DMSO; insoluble in H2O; ≥10.25 mg/mL in EtOH
  • form powder
  • color white to beige
  • FDA UNII Y7RG737FY6
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
BX-912 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1086
  • Product name : BX-912
  • Purity: ≥95% (HPLC)
  • Packaging: 5MG
  • Price: ₹9845.7
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1086
  • Product name : BX-912
  • Purity: ≥95% (HPLC)
  • Packaging: 25MG
  • Price: ₹39804.6
  • Updated: 2022/06/14
  • Buy: Buy

BX-912 Chemical Properties,Usage,Production

  • Description 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. BX-912 is a potent, ATP-competitive inhibitor of PDK1 (IC50 = 26 nM). It less effectively inhibits a panel of related serine-threonine kinases. BX-912 has been used to evaluate the role of PDK1 in kinase activation and cell survival.
  • Uses A selective potent PDK-1 inhibitor with an IC50 of 12 nM.
  • Uses BX-912 is a selective potent 3-Phosphoinositide-dependent Kinase-1 (PDK1) inhibitor. BX-192 shows potential anticancer properties as it inibits PDK1 activity towards the signaling pathway in cancer cell growth, survival and tumor angiogenesis.
  • Definition ChEBI: N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide is a member of ureas.
  • target PDK-1
  • References [1] feldman ri1, wu jm, polokoff ma, kochanny mj, dinter h, zhu d, biroc sl, alicke b, bryant j, yuan s, buckman bo, lentz d, ferrer m, whitlow m, adler m, finster s, chang z, arnaiz do. novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. j biol chem. 2005 may 20;280(20):19867-74. epub 2005 mar 16.
BX-912 Preparation Products And Raw materials
Raw materials
Preparation Products
BX-912 Suppliers
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BX-912 Spectrum
702674-56-4, BX-912Related Search:
  • PI3K
  • mTOR
  • Akt
  • Inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1).
  • Inhibitors
  • 信号转导通路激酶抑制剂
  • 药靶配体
  • 合成有机化合物配体
  • 抑制剂
  • 细胞生物学试剂
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • C20H23BrN8O
  • BX-912 |CAS 702674-56-4
  • 化合物BX912,10 MM DMSO 溶液
  • BX-912,PDK1 抑制剂
  • N-(3-((4-((2-(1H-咪唑-5-基)乙基)氨基)-5-溴嘧啶-2-基)氨基)苯基)吡咯烷-1-甲酰胺
  • N-[3-[[4-[[2-(4-咪唑基)乙基]氨基]-5-溴-2-嘧啶基]氨基]苯基]吡咯烷-1-甲酰胺
  • 化合物BX912
  • PDK1抑制剂(BX-912)
  • N-[3-[[5-溴-4-[[2-(1H-咪唑-5-基)乙基]氨基]-2-嘧啶基]氨基]苯基]-1-吡咯烷甲酰胺
  • 702674-56-4
  • BX-912, 10 mM in DMSO
  • Apoptosis,PDK-1,inhibit,BX912,BX-912,Inhibitor,BX 912
  • N-[3-[[4-[[2-(4-Imidazolyl)ethyl]amino]-5-bromo-2-pyrimidinyl]amino]phenyl]pyrrolidine-1-carboxamide
  • N-(3-((4-((2-(1H-imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide
  • 1-Pyrrolidinecarboxamide, N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-
  • CS-339
  • BX-912, >=98%
  • BX9121-PYRROLIDINECARBOXAMIDE,N-[3-[[5-BROMO-4-[[2-(1H-IMIDAZOL-4-YL)ETHYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-
  • N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX-912
  • BX-912 N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
  • N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
  • N-(3-((4-((2-(1H-Imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-c
  • N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX912/BX-912 N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide BX-912 N-[3-[[5-Bromo-4-[[2-(1H-imid
  • BX912/BX-912
  • N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
  • PYRROLIDINE-1-CARBOXYLIC ACID (3-(5-BROMO-4-[2-(1H-IMIDAZOL-4-YL)-ETHYLAMINO]-PYRIMIDIN-2-YLAMINO)-PHENYL)-AMIDE
  • BX 912
  • 1-PYRROLIDINECARBOXAMIDE, N-[3-[[5-BROMO-4-[[2-(1H-IMIDAZOL-4-YL)ETHYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-

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