Description
Inosine-5''-monophosphate (IMP) is a substrate of IMP dehydrogenase (IMPDH), a NAD
+-dependent enzyme that generates xanthosine monophosphate. This is a rate-limiting step in the generation of guanosine monophosphate, which is important for DNA, RNA, and glycoprotein synthesis. Inhibitors of IMPDH, including ribavirin (Item No.
16757) and mycophenolate mofetil (Item No.
13988), have potential applications as antiviral and anti-cancer drugs. 5-Ribonucleosides, including IMP, are also involved in potentiating the umami taste sensation.
Uses
Inosine-5''-monophosphate Sodium Salt Hydrate can be used for synthesis of fresh sauce for casserole. It is a sodium salt hydrate form of Inosine 5''-monophosphate (I665003), which can be used in combination with an immune checkpoint inhibitor for cancer immunotherapy.
General Description
Inosine-5'-monophosphate Disodium Salt octahydrate is a stabilised water-soluble form of inosine-5′-monophosphate disodium (5′-IMPNa2), which contributes to the bioavailability of IMP in the human body. The substance is also used for solubility, crystal and spectral structure studies.
References
[1] WILLIAM J. WATKINS. Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 13: Pages 3479-3483. DOI:
10.1016/j.bmcl.2006.03.097[2] GIRISH S NAIK Manoj G T. A Pharmacological Profile of Ribavirin and Monitoring of its Plasma Concentration in Chronic Hepatitis C Infection[J]. Journal of Clinical and Experimental Hepatology, 2012, 2 1: Pages 42-54. DOI:
10.1016/s0973-6883(12)60090-5[3] KATHERINE L B BORDEN Biljana C K. Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond[J]. Leukemia & Lymphoma, 2010, 51 10: 1805-1815. DOI:
10.3109/10428194.2010.496506[4] T. KONDOH K T. Mechanisms of Umami Taste Transduction and Umami Preference[J]. Journal of the Society of Brewing, Japan, 2001, 12 1: 829-847. DOI:
10.6013/jbrewsocjapan1988.96.829
