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DMT-2′O-Methyl-rC(ac) Phosphoramidite

DMT-2′O-Methyl-rC(ac) Phosphoramidite Structure
DMT-2′O-Methyl-rC(ac) Phosphoramidite
  • CAS No.199593-09-4
  • Chemical Name:DMT-2′O-Methyl-rC(ac) Phosphoramidite
  • CBNumber:CB21871625
  • Molecular Formula:C42H52N5O9P
  • Formula Weight:801.86
  • MOL File:199593-09-4.mol
DMT-2′O-Methyl-rC(ac) Phosphoramidite Property
  • Melting point 102 - 104°C
  • storage temp. Sealed in dry,2-8°C
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form powder
  • pka 10.18±0.20(Predicted)
  • color white to off-white
  • biological source non-animal source (no BSE/TSE risk)
  • InChIKey WNWUMIPFLOKTEZ-UAQIPLLRSA-N
  • SMILES O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,39,42,r|
  • UNSPSC Code 41116105
  • NACRES NA.51
Safety
  • Safety Statements  :24/25
  • WGK Germany  :3
  • HS Code  :29349990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
DMT-2′O-Methyl-rC(ac) Phosphoramidite Price More Price(6)
  • Brand: Sigma-Aldrich(India)
  • Product number: C213180
  • Product name : DMT-2′O-Methyl-rC(ac) Phosphoramidite
  • Purity: configured for PerkinElmer, configured for Polygen
  • Packaging: 1G
  • Price: ₹8508.45
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C213180
  • Product name : DMT-2′O-Methyl-rC(ac) Phosphoramidite
  • Purity: configured for PerkinElmer, configured for Polygen
  • Packaging: 0.5G
  • Price: ₹8952.28
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C213130
  • Product name : DMT-2′O-Methyl-rC(ac) Phosphoramidite
  • Purity: configured for ABI
  • Packaging: 1G
  • Price: ₹8118.75
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C213130
  • Product name : DMT-2′O-Methyl-rC(ac) Phosphoramidite
  • Purity: configured for ABI
  • Packaging: 0.5G
  • Price: ₹8952.28
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C213100
  • Product name : DMT-2′O-Methyl-rC(ac) Phosphoramidite
  • Purity: 
  • Packaging: 100G
  • Price: ₹647086.03
  • Updated: 2022/06/14
  • Buy: Buy

DMT-2′O-Methyl-rC(ac) Phosphoramidite Chemical Properties,Usage,Production

  • Uses 2''-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.
  • Application 2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rC(ac) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
    Diagnostic probes
    Aptamer and ribozyme development
    Mixed 2′O-Methyl-RNA/DNA antisense molecules
  • General Description DMT-2′O-Methyl-rC(ac) Phosphoramidite is one of the 2′O-Methyl RNA monomers that feature methoxy groups at the 2′-position. Themethoxy groups are perfectly stable in all conditions employed in theassembly of oligonucleotides by automated phosphoramidite synthesis, andin all standard alkaline deprotection conditions.Its key features include:
    High yield of crude oligonucleotides
    Compatible with DNA synthesis
    Can be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides
    Recommended deprotection conditions are 8 hours at 55 °C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
    Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradation
    Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers)
    2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry
DMT-2′O-Methyl-rC(ac) Phosphoramidite Preparation Products And Raw materials
Raw materials
Preparation Products
DMT-2′O-Methyl-rC(ac) Phosphoramidite Suppliers
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DMT-2′O-Methyl-rC(ac) Phosphoramidite Spectrum
199593-09-4, DMT-2′O-Methyl-rC(ac) PhosphoramiditeRelated Search:
  • Amidite
  • 抑制剂
  • 亚磷酰胺单体-2'-OMe Phosphoramidites
  • 原料药
  • 核苷单体及高端辅料
  • 亚磷酰胺单体-□ 2'-OMe amidite
  • 生物化工
  • 核酸合成原料
  • 核苷原料
  • 小核酸药物相关原料
  • 亚磷酰胺单体
  • 高端化学品
  • 有机化合物
  • 有机化工
  • 化学试剂
  • 核酸
  • C42H52N5O9P
  • 胞苷杂质14
  • DMT-2'-O-甲基-RC(AC)亚磷酰胺
  • DMT-2'-O-ME-C(AC)-CE 亚磷酰胺单体
  • 化合物 2'-OME-AC-C PHOSPHORAMIDITE
  • N4-ACETYL-5'-O-(4, 4'-DIMETHOXYTRITYL)-2'-O-METHYL-CYTIDINE-3'-CE-PHOSPHORAMIDITE
  • 2'-OME-AC-C-CE
  • DMT-2'-O-甲基-RC(AC)亚磷酰胺
  • 5'-O-DMT-2'-OME-AC-C PHOSPHOR AMIDITE
  • N4-AC-5'-O-DMT-2'-OME-C-CE
  • 2'-O-ME-亚磷酰胺单体2'-OME-C(AC)
  • 2'-OME-AC-C-CE-亚磷酰胺
  • N-乙酰基-5'-O-(4,4-二甲氧基三
  • (2R,3R,4R,5R)-5-(4-乙酰氨基-2-氧代嘧啶-1(2H)-基)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-4-甲氧基四氢呋喃-3-基(2-氰乙基)二异丙基亚磷酰胺
  • 2'-OME-C(AC)亚磷酰胺单体
  • N4-乙酰基-5'-O-DMT-2'-甲氧基胞苷-3'-氰乙氧基亚磷酰胺
  • 2'-OME-AC-RC -CE亚磷酰胺单体
  • 2'-OME-AC-RC 亚磷酰胺单体
  • 2-O-ME-RC(AC) 亚磷酰胺单体
  • 2'-OME-AC-C 亚磷酰胺单体
  • N-乙酰基-5'-O-(4,4-二甲氧基三苯甲基)-2'-O-甲基胞苷-3'-(2-氰基乙基-N,N-二异丙基)亚磷酰胺
  • 甲氧RC
  • 199593-09-4
  • Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
  • Cytidine Impurity 14
  • Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
  • DMT-2'O-METHYL-RC(AC) PHOSPHORAMIDITE
  • 2'-OMe-N-Ac CytidineAmidite
  • 2'-OMe-rC(Ac)Phosphoramidite
  • 2'-OMe-Ac-C CE Phosphoramidite
  • 2'-OMe-C(Ac)-CE-Phosphoramidite
  • DMT-2'-O-Me-C(Ac)-CE Phosphoramidite
  • 2'-OMe-Ac-C Phosphoramidite
  • 5'-ODMT-2'-OMe-N-Ac Cytidine-3'-OCEPA
  • 2’-OMe -dC(Ac) Amidite
  • DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite
  • 2'-OMe-N-Ac Cytidine?Amidite
  • DMT-2’-OMe-C(Ac)-CE Phosphoramidite
  • N4-Ac-5'-O-DMT-2'-OMe-C-CE
  • "DMT-2'-O-Me-dC(Ac) Phosphoramidite"
  • DMT-2-O-ME-C-CE Phosphoramidite
  • 5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite

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