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squalamine

squalamine Structure
squalamine
  • CAS No.148717-90-2
  • Chemical Name:squalamine
  • CBNumber:CB21321973
  • Molecular Formula:C34H65N3O5S
  • Formula Weight:627.96
  • MOL File:148717-90-2.mol
squalamine Property
  • Density 1.13±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO : 100 mg/mL (159.25 mM)
  • form Solid
  • pka -3.49±0.18(Predicted)
  • color Light yellow to yellow
  • FDA UNII F8PO54Z4V7
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

squalamine Chemical Properties,Usage,Production

  • Uses Squalamine is an aminosterol broad-spectrum antibacterial drug present in shark tissue.
  • Definition ChEBI: Squalamine is a bile acid.
  • Biological Activity Squalamine (MSI-1256) is a compound with broad-spectrum antiviral activity.
  • Synthesis Squalamine is isolated from the stomach of spiny horn shark and sea green dog shark.
  • in vivo

    Squalamine (2 mg/kg; Intraperitoneal injection; 28 days) inhibits tumor growth in xenografted mice with breast cancer[2].
    Squalamine (20 mg; Single application; 0-3 days) has a decolonizing effect on S. aureus on the skin in a mouse model[3].
    Squalamine (20-120 mg/kg; Oral gavage; 5 days) restores the function of the mesenteric nervous system in PD mouse models[4].

    Animal Model:Female athymic mice aged 6 weeks old bearing breast tumor xenografts[2]
    Dosage:2 mg/kg
    Administration:Intraperitoneal injection (i.p.); 28 days
    Result:Significantly retarded the growth of tumors, but the combination with Trastuzumab (HY-P9907) was more effective.
    Suppressed MCF-7/HER-2 breast xenograft-associated angiogenesis.
    Animal Model:10 μL S. aureus suspension(108 cfu/mL) was applied to the female BALB/c mice skin[3]
    Dosage:20 mg
    Administration:Single application; 3 days
    Result:Reduced S. aureus viable cells by up to 4 log after two days compared with the control.
    Animal Model:PD mice models ( hSNCAA53T mice and PrP-A53T human α-syn overexpressing transgenic mice)[4]
    Dosage:20, 40, 80, or 120 mg/kg
    Administration:Oral gavage (i.g.); 5 days
    Result:Effectively restored disordered colonic motility in PD mice models.
    Increased colonic transit in PrP-A53T mice.
    Reduced myenteric intrinsic primary afferent neuron excitability in hSNCAA53T mice.
squalamine Preparation Products And Raw materials
Raw materials
Preparation Products
squalamine Suppliers
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squalamine Spectrum
148717-90-2, squalamineRelated Search:
  • 抑制剂
  • 通用生化试剂-天然产物
  • 药物
  • 肾上腺皮质激素与促肾上腺皮质激素
  • 激素及其有关药物
  • C34H67N3O5S
  • C34H65N3O5S
  • (3Β,5ALPHA,7ALPHA)-3-[[3-((4-氨基丁基)氨基)丙基]氨基]胆甾烷-7,24-二醇24-氢硫酸酯
  • 化合物 T12995
  • 角鲨胺?, >98%
  • 角鲨胺
  • (3Β,5Α,7Α)-3-[[3-((4-氨基丁基)氨基)丙基]氨基]胆甾烷-7,24-二醇24-氢硫酸酯
  • 148717-90-2
  • Cholestane-7,24-diol,3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3b,5a,7a,24R)-
  • Cholestane-7,24-diol, 3-[[3-[(4-aminobutyl)amino]propyl]amino]-, 24-(hydrogen sulfate), (3β,5α,7α,24R)-
  • Squalamine, >98%
  • MSI 1256
  • (3β，5α，7α)-3-[[3-((4-Aminobutyl)amino)propyl]amino]cholestane-7，24-diol-24-hydrogen sulfate

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