ChemicalBook CAS DataBase List 148717-90-2

148717-90-2

Name	squalamine
CAS	148717-90-2
Molecular Formula	C34H65N3O5S
MDL Number	MFCD15146903
Molecular Weight	627.969
MOL File	148717-90-2.mol

Chemical Properties

density	1.13±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (159.25 mM)
form	Solid
pka	-3.49±0.18(Predicted)
color	Light yellow to yellow

Raw materials And Preparation Products

Hazard Information

Uses

Squalamine is an aminosterol broad-spectrum antibacterial drug present in shark tissue.

Definition

ChEBI: Squalamine is a bile acid.

Biological Activity

Squalamine (MSI-1256) is a compound with broad-spectrum antiviral activity.

Synthesis

Squalamine is isolated from the stomach of spiny horn shark and sea green dog shark.

in vivo

Squalamine (2 mg/kg; Intraperitoneal injection; 28 days) inhibits tumor growth in xenografted mice with breast cancer^[2].
Squalamine (20 mg; Single application; 0-3 days) has a decolonizing effect on S. aureus on the skin in a mouse model^[3].
Squalamine (20-120 mg/kg; Oral gavage; 5 days) restores the function of the mesenteric nervous system in PD mouse models^[4].

Animal Model:	Female athymic mice aged 6 weeks old bearing breast tumor xenografts^[2]
Dosage:	2 mg/kg
Administration:	Intraperitoneal injection (i.p.); 28 days
Result:	Significantly retarded the growth of tumors, but the combination with Trastuzumab (HY-P9907) was more effective. Suppressed MCF-7/HER-2 breast xenograft-associated angiogenesis.

Animal Model:	10 μL S. aureus suspension(10⁸ cfu/mL) was applied to the female BALB/c mice skin^[3]
Dosage:	20 mg
Administration:	Single application; 3 days
Result:	Reduced S. aureus viable cells by up to 4 log after two days compared with the control.

Animal Model:	PD mice models ( hSNCA^A53T mice and PrP-A53T human α-syn overexpressing transgenic mice)^[4]
Dosage:	20, 40, 80, or 120 mg/kg
Administration:	Oral gavage (i.g.); 5 days
Result:	Effectively restored disordered colonic motility in PD mice models. Increased colonic transit in PrP-A53T mice. Reduced myenteric intrinsic primary afferent neuron excitability in hSNCA^A53T mice.

storage

Store at -20°C

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