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Vatalanib Dihydrochloride

Vatalanib Dihydrochloride Structure
Vatalanib Dihydrochloride
  • CAS No.212141-51-0
  • Chemical Name:Vatalanib Dihydrochloride
  • CBNumber:CB21176854
  • Molecular Formula:C20H17Cl3N4
  • Formula Weight:419.74
  • MOL File:212141-51-0.mol
Vatalanib Dihydrochloride Property
  • Melting point 268-2700C
  • storage temp. Inert atmosphere,Store in freezer, under -20°C
  • solubility Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
  • form solid
  • color White or off-white
  • Water Solubility H2O: 2mg/mL, clear
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
  • CAS DataBase Reference 212141-51-0
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Risk Statements  :36/37/38
  • Safety Statements  :24/25
  • HS Code  :29333990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P271-P280
Vatalanib Dihydrochloride Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML2498
  • Product name : Vatalanib dihydrochloride
  • Purity: ≥98% (HPLC)
  • Packaging: 10MG
  • Price: ₹6689.85
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML2498
  • Product name : Vatalanib dihydrochloride
  • Purity: ≥98% (HPLC)
  • Packaging: 50MG
  • Price: ₹22526.83
  • Updated: 2022/06/14
  • Buy: Buy

Vatalanib Dihydrochloride Chemical Properties,Usage,Production

  • Description Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.
  • Chemical Properties White to Off-White Crystalline Powder
  • Uses Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.
  • Uses Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.
  • in vivo

    Vatalanib induces dose-dependent inhibition of the angiogenic response to VEGF and PDGF in both a growth factor implant model and a tumor cell-driven angiogenesis model after once-daily oral dosing (25-100 mg/kg). In the same dose range, Vatalanib also inhibits the growth and metastasesof several human carcinomas in nude mice without significant effect on circulating blood cells or bone marrow leukocytes[1].

  • IC 50 VEGFR2: 37 nM (IC50)
  • References 1) Wood?et al. (2000),?PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration;? Cancer Res.,?60?2178 2) Lin?et al. (2002),?The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in bone marrow microenvironment;? Cancer Res.,?62?5019
Vatalanib Dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Vatalanib Dihydrochloride Suppliers
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Vatalanib Dihydrochloride Spectrum
212141-51-0, Vatalanib DihydrochlorideRelated Search:
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Antineoplastic
  • Tyrosine Kinase Inhibitors
  • Heterocycles
  • 抑制剂
  • 药靶配体
  • 细胞生物学试剂
  • 科研试剂
  • 小分子抑制剂，天然产物
  • 蛋白酪氨酸激酶
  • 医药原料药
  • C20H15ClN42ClH
  • C20H15Cl2N42HCl
  • C20H15ClN42HCl
  • C20H17Cl3N4
  • 瓦他拉尼,10 MM DMSO 溶液
  • VATALANIB DIHYDROCHLORIDE,VEGFR TYROSINE KINASE抑制剂
  • 瓦他拉尼 (PTK787)二盐酸盐
  • 瓦他拉尼二盐酸盐 (VEGFR2/KDR抑制剂)
  • 瓦他拉尼二盐酸盐 D4 (双盐酸盐)
  • N-(4-氯苯基)-4-(吡啶-4-基甲基)酞嗪-1-胺二盐酸盐
  • VEGFR2/KDR抑制剂(VATALANIB)
  • 瓦他拉尼碱二盐酸盐
  • 瓦他拉尼
  • 瓦他拉尼二盐酸盐
  • N-(4-氯苯基)-4-(4-吡啶甲基)-1-酞嗪胺二盐酸盐
  • 瓦他拉尼(PTK787 ) 2HCL
  • 212141-51-0
  • Vatalanib dihydrochloride, 10 mM in DMSO
  • Vatalanib dihydrochloride, VEGFR tyrosine kinase inhibitor
  • Vatalinib 2HCl
  • CGP79787) 2HCl
  • 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, hydrochloride (1:2)
  • Vatalanib Dihydrochloride USP/EP/BP
  • PTK787 dihydrochloride
  • CGP-797870 dihydrochloride
  • ZK-222584 dihydrochloride
  • CS-465
  • Vatalanib (PTK787) diHydrochloride
  • Vatalanib dihydrochloride(2HCL)
  • Vatalanib (hydrochloride)
  • Vatalanib (PTK787) 2HCl
  • Vatalanib 2HCl (PTK787)
  • ZK 222584 (cpg-79787) 2HCl
  • N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride
  • CGP-79787, PTK 787, ZK222584
  • ZK-222584
  • PTK/ZK
  • CGP-79787D
  • CGP-79787
  • Vatalanib dihydrochloride (PTK787)
  • Vatalanib 2hcl((ZK-222584,PTK 787)
  • CGP-79787 Dihydrochloride
  • Vatalanib Dihydrochloride
  • N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Dihydrochloride
  • CGP-79787 Dihydrochlorid

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