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Batimastat

Batimastat Structure
Batimastat
  • CAS No.130370-60-4
  • Chemical Name:Batimastat
  • CBNumber:CB1874927
  • Molecular Formula:C23H31N3O4S2
  • Formula Weight:477.64
  • MOL File:130370-60-4.mol
Batimastat Property
  • Melting point 236-238°
  • Density 1.25±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility DMSO: ≥15mg/mL
  • form powder
  • pka 9.04±0.40(Predicted)
  • color white to tan
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
  • InChIKey XFILPEOLDIKJHX-QYZOEREBSA-N
  • NCI Dictionary of Cancer Terms batimastat
  • FDA UNII BK349F52C9
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
  • HS Code  :29349990
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
Batimastat Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0041
  • Product name : Batimastat
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹22375.28
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0041
  • Product name : Batimastat
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹89143.88
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 5.08408
  • Product name : InSolution Batimastat - CAS 130370-60-4 - Calbiochem
  • Purity: 
  • Packaging: 2MG
  • Price: ₹12940
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 196440
  • Product name : Batimastat - CAS 130370-60-4 - Calbiochem
  • Purity: Batimastat primarily used in Inhibition.
  • Packaging: 5MG
  • Price: ₹13100
  • Updated: 2022/06/14
  • Buy: Buy

Batimastat Chemical Properties,Usage,Production

  • Description Batimastat (130370-60-4) is a potent, broad spectrum MMP inhibitor (IC50 =3, 4, 4, 6 and 20 nM for MMPs -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human colon1, ovarian2 and prostate3 xenografts in vivo. Attenuates neuroinflammation following focal cerebral ischemia in mice.4 Inhibits α-secretase.5 Inhibits snake venom (Bothrops asper) lethality.6
  • Originator Batimastat,British Biotech
  • Uses Antineoplastic.
  • Uses Batimastat has been used to inhibit matrix metalloproteinases (MMPs) activity in various studies.
  • Therapeutic Function Antineoplastic
  • General Description A Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50 = 1.6 and 3.3 μM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo.
  • Biological Activity Potent, broad spectrum matrix metalloprotease (MMP) inhibitor (IC 50 values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo .
  • Biochem/physiol Actions Cell permeable: yes
  • Enzyme inhibitor This potent, broad-spectrum matrix metalloprotease, or MMP, inhibitor (FW = 477.64 g/mol; CAS 130370-60-4; Solubility: 96 mg/mL DMSO, <1 mg/mL H2O), also known by its code name BB-94 and its systematic name (2R,3S)-N4 -hydroxy-N1 -[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl) ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide, targets MMP-1 (IC50 = 3 nM), MMP-2 (IC50 = 4 nM), MMP-9 (IC50 = 4 nM), MMP-7 (IC50 = 6 nM) and MMP-3 (IC50 = 22 nM). Matrix metalloproteinases have been implicated in the growth and spread of metastatic tumors, and Batimastat not only prevents colonization of secondary organs by B16-BL6 cells, but limits the growth of solid tumors. Animals receiving BB-94 (30 mg/kg, i.p., once daily for 60 days, followed by 3 times weekly) show a reduction in the median primary tumor weight from 293 mg in the control group to 144 mg in the treated group. BB-94 treatment also reduces the incidence of local and regional invasion. Batimastat also reduces in vivo growth of experimental hemangiomas, most probably by blocking endothelial cell recruitment by the transformed cells or by interfering with cell organization in vascular structures. Target(s): Trimeresurus mucrosquamatus (Taiwan habu) venom metalloproteinases; matrix metalloproteinases; interstitial collagenase, or MMP1; stromelysin, or MMP3; matrilysin, or MMP7; gelatinase A, or or MMP2; gelatinase B, or or MMP9; neutrophil collagenase, or MMP8; atrolysin C, or Crotalus atrox metalloendopeptidase c; membrane-type 1 matrix metalloproteinase, or MMP14; membrane-type 3 matrix metalloproteinase, or MMP-16; ADAM 17 endopeptidase, or tumor necrosis factor-a converting enzyme; TACE (13- 15); a-secretase; ADAM TS-4 endopeptidase, or aggrecanase; macrophage elastase, or MMP12.
  • storage Store at -20°C
  • References 1) Wang et al. (1994), Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice; Cancer Res., 54 4726 2) Davies et al. (1993), A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma zenografts; Cancer Res., 53 2087 3) Lein et al. (2000), Synthetic inhibitor of matrix metalloproteinase (batimastat) reduces prostate cancer growth in an orthotopic rat model; Prostate, 43 77 4) Park et al. (2011), Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice; Korean J. Physiol. Pharmacol., 15 115 5) Dubrovskaya et al. (2006), Effects of an inhibitor of alpha-secretase, which metabolizes the amyloid peptide precursor, on memory formation in rats; Neurosci. Behav. Physiol., 36 911 6) Rucavado et al. (2004), Effects of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation; Toxicon, 43 417
Batimastat Preparation Products And Raw materials
Raw materials
Preparation Products
Batimastat Suppliers
Global(120)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Nextpeptide Inc
  • Tel：+86-0571-81612335<br/>+8613336028439
  • Email：sales@nextpeptide.com
  • Country：China
  • ProdList：19908
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
Batimastat Spectrum
130370-60-4, BatimastatRelated Search:
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  • 抑制剂
  • 巴马司他,10 MM DMSO 溶液
  • BATIMASTAT (BB-94),MATRIX METALLOPROTEASE (MMP)抑制剂
  • BATIMASTAT (BB-94) (DMSO SOLUTION),MATRIX METALLOPROTEASE (MMP)抑制剂
  • (2S,3R)-N1-羟基-3-异丁基-N4-((S)-1-(甲基氨基)-1-氧代-3-苯基丙-2-基)-2-((噻吩-2-基硫代)甲基)琥珀酰胺
  • 广谱MMP抑制剂(BATIMASTAT)
  • (2S,3R)-N-羟基-N'-[(2S)-1-甲基氨基-1-氧代-3-苯基丙-2-基]-3-异丁基-2-(噻吩-2-基硫甲基)丁二酰胺
  • 巴马司他
  • 130370-60-4
  • Batimastat, 10 mM in DMSO
  • Batimastat (BB-94), Matrix metalloprotease (MMP) inhibitor
  • Batimastat (BB-94) (DMSO solution), Matrix metalloprotease (MMP) inhibitor
  • (2S,3R)-N1-Hydroxy-3-isobutyl-N4-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-2-((thiophen-2-ylthio)methyl)succinamide
  • BB94;BB 94
  • InSolution Batimastat - CAS 130370-60-4 - Calbiochem
  • Batimastat - CAS 130370-60-4 - Calbiochem
  • Batimastat (2S,3R)-N-Hydroxy-N'-[(2S)-1-methylamino-1-oxo-3-phenylpropan-2-yl]-3-(2-methylpropyl)-2-(thiophen-2-ylsulfanylmethyl)butanediamide
  • (2S,3R)-N-Hydroxy-N'-[(2S)-1-methylamino-1-oxo-3-phenylpropan-2-yl]-3-(2-methylpropyl)-2-(thiophen-2-ylsulfanylmethyl)butanediamide Batimastat
  • N4-hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-, (2R,3S)-
  • BatiMastat (MMP Inhibitor)
  • (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
  • Batimastat
  • (2S,3R)-N-Hydroxy-N'-[(2S)-1-methylamino-1-oxo-3-phenylpropan-2-yl]-3-(2-methylpropyl)-2-(thiophen-2-ylsulfanylmethyl)butanediamide
  • BB 94
  • Butanediamide, N4-hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-, (2R,3S)-

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