ChemicalBook > CAS DataBase List > N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Structure
N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
  • CAS No.127243-85-0
  • Chemical Name:N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
  • CBNumber:CB1853005
  • Molecular Formula:C20H20BrN3O2S
  • Formula Weight:446.36
  • MOL File:127243-85-0.mol
N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Property
  • Melting point 195-200°C
  • Boiling point 639.7±65.0 °C(Predicted)
  • Density 1.436
  • storage temp. 2-8°C
  • solubility H2O: ≥10 mg/mL
  • form powder
  • pka 10.43±0.50(Predicted)
  • color off-white
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
  • CAS DataBase Reference 127243-85-0(CAS DataBase Reference)
  • FDA UNII M876330O56
  • UNSPSC Code 12352302
  • NACRES NA.77
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
  • HS Code  :29350090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H335-H315-H302-H312-H319-H332
  • Precautionary statements P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P264-P280-P305+P351+P338-P337+P313P-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362

N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

  • Description H-89 (127243-85-0) is a commonly used inhibitor of protein kinase A (PKA? IC50?= 140 nM).? Inhibits a variety of other kinases including S6K1 (IC50?= 80 nM), MSK1 (120 nM), ROCK II (270 nM), PKBα (2.6 μM), PKD, PRK2, RSK1 and 2, SGK, AMPK, CHK1 and MAPKAP-K1b (2.8 μM).1,2
  • Chemical Properties White Solid
  • Uses Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM.
  • Definition ChEBI: A member of the class of isoquinolines that is the sulfonamide obtained by formal condensation of the sulfo group of isoquinoline-5-sulfonic acid with the primary amino group of N1-[3-(4-bromophenyl)prop-2-en-1-yl]et ane-1,2-diamine.
  • General Description A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (Ki = 28.3 μM), Ca2+/calmodulin-dependent protein kinase II (Ki = 29.7 μM), protein kinase C (Ki = 31.7 μM), casein kinase I (Ki = 38.3 μM), and Rho Kinase II (IC50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 mM) by blocking the action of Rho kinase II.
  • Biological Activity Protein kinase A inhibitor that also inhibits several other kinases (IC 50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKB α and MAPKAP-K1b).
  • Biochem/physiol Actions Target Ki: 48 nM for protein kinase A
  • References 1) Lochner and Moolman (2006),?The many faces of H89: a review; Cardiovasc. Drugs,?24?261 2) Bain?et al. (2007),?The selectivity of protein kinase inhibitors: a further update; Biochem.J.?408(Pt3)?297
N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Suppliers
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N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE Spectrum
127243-85-0, N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDERelated Search:
  • Protein Kinase Inhibitors and Activators
  • Inhibitor
  • 抑制剂
  • 医药中间体
  • 定制化学品
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Serine/Threonine Kinase Inhibitors
  • Protein Kinase A (PKA)
  • Kinase/Phosphatase Biology
  • C20H20BrN3O2S2ClH
  • C20H20BrN3O2S
  • C20H20BrN3O2S2HCl
  • C20H22BrCl2N3O2S
  • C20H22BrN3O2SCl2
  • 化合物 H-89
  • (BASE),H-89 & H-89 2HCL游离,盐酸盐
  • H-89二盐酸盐, 一种高效的选择性PKA抑制剂
  • N - [2 - (P溴肉桂氨基酸乙基] -5 - 异喹啉磺胺类药物
  • N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺二盐酸盐(H-89二盐酸盐)
  • N-[2-[P-溴苯丙烯盐基氨基]乙基]-5-异喹啉磺酰胺
  • N-[2-[[3-(4-溴苯基)-2-丙烯-1-基]氨基]乙基]-5-异喹啉磺酰胺
  • 127243-85-0
  • H-89 free base
  • N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLI
  • N-[2-[3-(4-bromophenyl)prop-2-enylamino]ethyl]-5-isoquinolinesulfonamide dihydrochloride
  • H 89 (Protein kinase inhibitor H-89
  • CS-2385
  • H-89, Dihydrochloride - CAS 127243-85-0 - Calbiochem
  • H 89 2HCl,H 89 dihydrochloride
  • H-89 dihydrochloride, 98%, a potent and selective inhibitor of PKA
  • (E)-N-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide
  • N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide
  • H-89 ＆ H-89 2HCl
  • H-89 hcl
  • Protein kinase inhibitor H-89
  • 5-IsoquinolinesulfonaMide,N-[2-[[3-(4-broMophenyl)-2-propen-1-yl]aMino]ethyl]-
  • N-(2-((3-(4-BroMophenyl)allyl)aMino)ethyl)isoquinoline-5-sulfonaMide dihydrochloride
  • N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-isoquinolinesulfonamide
  • N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide, Di-HCl Salt
  • H-89, Dihydrochloride Salt >99%
  • N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamidedihydrochloride
  • H89 DIHCL
  • H-89 dihydrochloride,98%
  • N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE
  • N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
  • N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, DIHYDROCHLORIDE
  • N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL
  • N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
  • H-89 HYDROCHLORIDE
  • H-89 DIHYDROCHLORIDE
  • H-89

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