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Glycyrrhizic acid ammonium salt

CAS No.53956-04-0
Chemical Name:Glycyrrhizic acid ammonium salt
CBNumber:CB1492372
Molecular Formula:C42H65NO16
Formula Weight:839.97
MOL File:53956-04-0.mol

Glycyrrhizic acid ammonium salt Property

Melting point >200°C (dec.)
Boiling point 768.56°C (rough estimate)
Density 1.1846 (rough estimate)
FEMA 2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
refractive index 49 ° (C=1.5, EtOH)
storage temp. 2-8°C
solubility Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides.
form Powder or Crystals
color Yellow to yellow-green
Odor bland
optical activity [α]20/D +48±4°, c = 1% in ethanol: water (1:1)
BRN 3897076
Stability Hygroscopic
InChIKey ILRKKHJEINIICQ-YDYGGSECSA-N
LogP -0.9
CAS DataBase Reference 53956-04-0
Substances Added to Food (formerly EAFUS) GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
SCOGS (Select Committee on GRAS Substances) Ammoniated Glycyrrhizin
EWG's Food Scores 4
FDA UNII 3VRD35U26C
EPA Substance Registry System .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt (53956-04-0)
UNSPSC Code 85151701
NACRES NA.76

Safety

RIDADR :UN 3077 9 / PGIII
WGK Germany :2
RTECS :LZ6500000
F :3-10
HS Code :29389090

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H319
Precautionary statements P264-P280-P305+P351+P338-P337+P313

Glycyrrhizic acid ammonium salt Price More Price(11)

Brand: Sigma-Aldrich(India)
Product number: G2137
Product name : Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice)
Purity: ≥70% (HPLC)
Packaging: 25G
Price: ₹7599.15
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: G2137
Product name : Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice)
Purity: ≥70% (HPLC)
Packaging: 100G
Price: ₹14083.33
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 50531
Product name : Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice)
Purity: ≥95.0% (NT)
Packaging: 10G
Price: ₹6072.83
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 91443
Product name : Glycyrrhizic acid ammonium salt
Purity: analytical standard, suitable for HPLC
Packaging: 10MG
Price: ₹12513.7
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 50531
Product name : Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice)
Purity: ≥95.0% (NT)
Packaging: 50G
Price: ₹21087.1
Updated: 2022/06/14
Buy: Buy

Glycyrrhizic acid ammonium salt Chemical Properties,Usage,Production

Description § 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza. Licorice extract is that portion of the licorice root that is, after maceration, extracted by boiling water. The extract can be further purified by filtration and by treatment with acids and ethyl alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried powder. (2) Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation followed by neutralization with dilute ammonia. Monoammonium glycyrrhizinate (C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.
Chemical Properties Licorice (glycyrrhiza) root is the dried and ground rhizome and root portions of Glycyrrhiza glabra or other species of glycyrrhiza Ammoniated glycyrrhizin is prepared from the water extract of licorice root by acid precipitation, followed by neutral- ization with dilute ammonia Monoammonium glycyrrhizinate (C42H62O16NH45H2O) is prepared from ammoniated glycyrrhizin by solvent extraction and separation techniques.
Chemical Properties white to slightly yellow powder
Uses anti-cancer agent
Uses pharmaceutical excipient, GRAS, sweetener
Uses Glycyrrhizic acid ammonium salt is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings.
Uses Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl ammatory drugs with which Ammonium Glycyrrhizinate is associated.
Definition ChEBI: Monoammonium glycyrrhizinate is an organic molecular entity.
General Description Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
Biochem/physiol Actions Biologically active constituent in the sweet root of Glycyrrhiza species (licorice). Antiviral.
Anticancer Research Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide.
Safety Profile Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3.
target ROS
Purification Methods Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.]