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CILOSTAMIDE

CAS No.68550-75-4
Chemical Name:CILOSTAMIDE
CBNumber:CB1444199
Molecular Formula:C20H26N2O3
Formula Weight:342.43
MOL File:68550-75-4.mol

CILOSTAMIDE Property

Melting point 186～188℃
Boiling point 594.3±50.0 °C(Predicted)
Density 1.18±0.1 g/cm3(Predicted)
storage temp. 0-6°C
solubility Soluble in DMSO (up to 30 mg/ml).
form White solid
pka 11.12±0.70(Predicted)
color White
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
FDA UNII 45S5605Q18
UNSPSC Code 12352202
NACRES NA.77

Safety

RIDADR :3249
WGK Germany :3
HazardClass :6.1(b)
PackingGroup :III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H315-H319-H335
Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338

CILOSTAMIDE Price More Price(3)

Brand: Sigma-Aldrich(India)
Product number: C7971
Product name : Cilostamide
Purity: phosphodiesterase inhibitor
Packaging: 5MG
Price: ₹39500.43
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 231085
Product name : Cilostamide - CAS 68550-75-4 - Calbiochem
Purity: A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC?? = 70 nM).
Packaging: 10MG
Price: ₹27450.01
Updated: 2022/06/14
Buy: Buy

Brand: ALFA India
Product number: ALF-J65319-MA
Product name : Cilostamide
Purity:
Packaging: 10mg
Price: ₹22027
Updated: 2022/05/26
Buy: Buy

CILOSTAMIDE Chemical Properties,Usage,Production

Description Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and 50 nM).1,2 Blocks PKB/Akt signaling pathway downstream via inhibition of Akt-activated PDE3B.3 Cilostamide reverses the effect of leptin on food intake and body weight.4
Uses Serotonin receptor ligand
Uses Cilostamide (OPC 3689) is a specific phosphodiesterase 3 (PDE3) inhibitor.
Definition ChEBI: N-cyclohexyl-N-methyl-4-[(2-oxo-1H-quinolin-6-yl)oxy]butanamide is a member of quinolines.
Biological Activity Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC 50 values are 0.027 and 0.050 μ M for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC 50 = 16.8 μ M); anti-thrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
Biochem/physiol Actions Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.
storage Store at RT
References 1) Hidaka et al. (1979), Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation; J. Pharmacol. Exp. Ther., 211 26 2) Christensen and Torphy et al. (1994), Isozyme-Selective Phosphodiesterase Inhibitors as Antiasthmatic Agents; Annu. Rep. Med. Chem., 29 185 3) Ahmad et al. (2000), Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells; J. Immunol., 164 4678 4) Zhao et al. (2002), A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding; Nat. Neuroscience, 5 727