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LAPACHOL

CAS No.84-79-7
Chemical Name:LAPACHOL
CBNumber:CB1339480
Molecular Formula:C15H14O3
Formula Weight:242.27
MOL File:84-79-7.mol

LAPACHOL Property

Melting point 141-143 °C(lit.)
Boiling point 325.09°C (rough estimate)
Density 1.2077 (rough estimate)
refractive index 1.5740 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility ethanol: soluble10mg/mL, clear, light yellow to yellow
pka 4.81±0.10(Predicted)
form Solid
Colour Index 75490
color Yellow to Dark Yellow
Merck 13,5382
InChIKey CIEYTVIYYGTCCI-UHFFFAOYSA-N
LogP 2.516 (est)
CAS DataBase Reference 84-79-7
EWG's Food Scores 1
FDA UNII B221938VB6
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xn
Risk Statements :20/21/22-36/37/38
Safety Statements :26-36
WGK Germany :3
RTECS :QL8750000
Toxicity :LD50 in male, female BALB/c mice (g/kg): 0.487; 0.792 orally (Morrison)

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P301+P312+P330

LAPACHOL Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: 142905
Product name : Lapachol
Purity: 98%
Packaging: 250MG
Price: ₹8447.1
Updated: 2022/06/14
Buy: Buy

LAPACHOL Chemical Properties,Usage,Production

Description Lapachol, a benzoquinone, is a secondary allergen in teak (Tectona grandis).
Occurrence Lapacol (CI Natural Yellow 16; CI 75490) (lapachic acid, taiguie acid, tecomin) is a yellow pigment occurring in the wood of trees of the genus Tecoma, native to the West Indies and tropical South America. The shavings of the wood, treated with lime water, give an extract that dyes cotton yellow.
Uses antineoplastic, antifungal
Uses It was used in the synthesis of the lapachol metal complexes.
Uses Lapachol was used in the synthesis of the lapachol metal complexes.
Definition ChEBI: Lapachol is a hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone substituted by hydroxy and 3-methylbut-2-en-1-yl groups at positions 2 and 3, respectively. It is a natural compound that exhibits antibacterial and anticancer properties, first isolated in 1882 from the bark of Tabebuia avellanedae. It has a role as a plant metabolite, an antineoplastic agent, an antibacterial agent and an anti-inflammatory agent. It is a hydroxy-1,4-naphthoquinone and an olefinic compound.
General Description Lapachol is natural naphthoquinone compound derived from Bignoniaceae (Tabebuia sp.).
Biochem/physiol Actions Lapachol has antimicrobial properties against many pathogens. It has anti-inflammatory, analgesic and antibiotic properties. It is inhibitor of epithelial tumors in Drosophila melanogaster heterozygote.
Contact allergens Lapachol, a benzoquinone, is a secondary allergen in teak (Tectona grandis L., Verbenaceae family), a wood largely used for various indoor and outdoor applications (doors, windows, etc.) because of its strong durability. It has similar reactivity to deoxylapachol. Seealso Chap. 46
Purification Methods Crystallise Lapachol from pet ether/EtOH, EtOH or Et2O. [Beilstein 8 H 326, 8 I 644, 8 II 365, 8 III 2720.]