ChemicalBook > CAS DataBase List > 4-Hydroxythiobenzamide
4-Hydroxythiobenzamide
4-Hydroxythiobenzamide
- CAS No.25984-63-8
- Chemical Name:4-Hydroxythiobenzamide
- CBNumber:CB1314575
- Molecular Formula:C7H7NOS
- Formula Weight:153.2
- MOL File:25984-63-8.mol
4-Hydroxythiobenzamide Property
- Melting point 181-185℃
- Boiling point 320.4±44.0 °C(Predicted)
- Density 1.338±0.06 g/cm3(Predicted)
- storage temp. Keep in dark place,Inert atmosphere,Room temperature
- solubility DMSO (Slightly), Methanol (Slightly)
- form Solid
- pka 9.24±0.26(Predicted)
- color Light Yellow
- InChI InChI=1S/C7H7NOS/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10)
- InChIKey VDTNKXSVUGXUOJ-UHFFFAOYSA-N
- SMILES C1(C(N)=S)=CC=C(O)C=C1
- CAS DataBase Reference 25984-63-8(CAS DataBase Reference)
- FDA UNII ZZ8JR2736Y
- UNSPSC Code 12352200
Safety
- Hazard Codes :Xi
- Risk Statements :20/21/22-36/37/38-43-22
- Safety Statements :26-36/37/39-36/37
- HS Code :29242990
-
NFPA 704:
1 2 0
-
Symbol(GHS)
- Signal wordWarning
- Hazard statements H315-H319-H302-H335
- Precautionary statements P280h-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
4-Hydroxythiobenzamide Price
More Price(2)
- Brand: TCI Chemicals (India)
- Product number: H1308
- Product name : 4-Hydroxythiobenzamide
- Purity:
- Packaging: 5G
- Price: ₹5000
- Updated: 2022/05/26
- Buy: Buy
- Brand: TCI Chemicals (India)
- Product number: H1308
- Product name : 4-Hydroxythiobenzamide
- Purity:
- Packaging: 25G
- Price: ₹15900
- Updated: 2022/05/26
- Buy: Buy
4-Hydroxythiobenzamide Chemical Properties,Usage,Production
- Uses 4-Hydroxythiobenzamide(25984-63-8) is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.
- Chemical Properties 4-Hydroxythiobenzamide has an appearance ranging from light orange to yellow to green, powder to crystalline, melting point 192 °C, soluble in methanol.
- Uses febuxostat intermediate
- Uses 4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease.
-
Synthesis
4-Hydroxythiobenzamide is an important intermediate of Febuxostat, a new anti-gout drug. A patent discloses a method for preparing p-hydroxythiobenzamide. Specifically, a certain amount of water, p-cyanophenol, sodium hydrosulfide, and secondary amine are mixed evenly. At a specific temperature, an organic weak acid is added dropwise. After the reaction is completed, the mixture is filtered, and the filter cake is dried to obtain 4-Hydroxythiobenzamide.
4-Hydroxythiobenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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25984-63-8, 4-HydroxythiobenzamideRelated Search:
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- 25984-63-8
- pharmaceutical intermediate
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