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ALPRENOLOL HYDROCHLORIDE

ALPRENOLOL HYDROCHLORIDE Structure
ALPRENOLOL HYDROCHLORIDE
  • CAS No.13707-88-5
  • Chemical Name:ALPRENOLOL HYDROCHLORIDE
  • CBNumber:CB1284148
  • Molecular Formula:C15H24ClNO2
  • Formula Weight:285.81
  • MOL File:13707-88-5.mol
ALPRENOLOL HYDROCHLORIDE Property
  • Melting point 107-109°
  • storage temp. 2-8°C
  • solubility H2O: 50 mg/mL
  • form powder
  • color off-white
  • Water Solubility Soluble in water (100mM)
  • Stability Hygroscopic
  • InChIKey RRCPAXJDDNWJBI-UHFFFAOYSA-N
  • CAS DataBase Reference 13707-88-5
  • EWG's Food Scores 1
  • FDA UNII 2502C2OIRK
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • RIDADR  :3249
  • WGK Germany  :3
  • RTECS  :UA5425000
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • Toxicity :LD50 in mice, rats, rabbits (mg/kg): 278.0, 597.0, 337.3 orally (Marmo)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P301+P312+P330

ALPRENOLOL HYDROCHLORIDE Chemical Properties,Usage,Production

  • Chemical Properties White or almost white, crystalline powder or colourless crystals.
  • Originator Aptol,Globopharm,Switz.
  • Uses Alprenlol Hydrochloride acts as a β-adrenergic blocking agent against arrhythmia.
  • Uses aldose reductase inhibitor
  • Manufacturing Process A solution of 24.6 g of o-allyl-epoxypropoxybenzene dissolved in 250 ml of absolute ethanol saturated with ammonia was placed in an autoclave and heated on a steam-bath for 2 hours. The alcohol was then removed by distillation and the residue was redissolved in a mixture of methanol and ethylacetate. Hydrogen chloride gas was introduced into the solution. The hydrochloride salt was then precipitated by the addition of ether to yield 11.4 g of product. Five grams of the amine-hydrochloride thus formed were dissolved in 50 ml of methanol and 9 ml of acetone. The resulting solution was cooled to about 0°C. At this temperature 5 g of sodium borohydride were added over a period of 1 hour. Another 2.2 ml of acetone and 0.8 g of sodium borohydride were added and the solution was kept at room temperature for 1 hour, after which 150 ml of water were added to the solution. The solution was then extracted with three 100-ml portions of ether which were combined, dried over potassium carbonate, and evaporated. The free base was then recrystallized from petrol ether (boiling range 40-60°C) to yield 2.7 g of material having a melting point of 57°C.
    The corresponding hydrochloride was prepared by dissolving 2 g of the product, prepared above, in 20 ml of acetone, and adding to the resulting solution acetone saturated with hydrogen chloride until the pH was reduced to about 3. The precipitated hydrochloride salt was then recrystallized from acetone.
  • Therapeutic Function Beta-adrenergic blocker
  • Biological Activity β -adrenoceptor ( β 2 > β 1 > β 3 ) and 5-HT 1A receptor antagonist.
  • storage room temperature (desiccate)
ALPRENOLOL HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ALPRENOLOL HYDROCHLORIDE Suppliers
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ALPRENOLOL HYDROCHLORIDE Spectrum
13707-88-5, ALPRENOLOL HYDROCHLORIDERelated Search:
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  • 13707-88-5
  • Alprenolol hydrochloride, 10 mM in DMSO
  • *Amylmetacresol Impurity 2 (Amylmetacresol EP Impurity B )
  • inhibit,5-HT Receptor,5-HT1B,Inhibitor,β-adrenoceptor,5-hydroxytryptamine Receptor,Serotonin Receptor,Alprenolol hydrochloride,anti-hypertensive,anti-arrhythmic,5-HT1A,(RS)-Alprenolol,dl-Alprenolol,Alprenolol,anti-anginal
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  • 1-(2-Allylphenoxy)-3-(isopropylaMino)propan-2-ol hydrochloride
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  • 1-[(1-Methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-2-propanolhydrochloride
  • propan-2-ol hydrochloride
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  • Atetenenol
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  • Applobal
  • Alfeprol
  • 1-(2-Allylphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride
  • 2-Propanol, 1-(o-allylphenoxy)-3-(isopropylamino)-, hydrochloride
  • 2-Propanol, 1-(1-methylethyl)amino-3-2-(2-propenyl)phenoxy-, hydrochloride
  • ALPRENOLOL HYDROCHLORIDE B-ADRENERGIC RE CEPTOR
  • Alprenolol HCl
  • yobir
  • regletin
  • 1-(o-allylphenoxy)-3-(isopropylamino)-2-propanohydrochloride
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  • L-1[2-ALLYLPHENOXY]3-ISOPROPYL-AMINOPROPAN 2-OL HYDROCHLORIDE HYDRATE
  • L-ALPRENOLOL HYDROCHLORIDE HYDRATE
  • ALPRENOLOL HYDROCHLORIDE
  • 1-[O-ALLYLPHENOXY]-3-[ISOPROPYLAMINO]-2-PROPANOL HYDROCHLORIDE
  • h56/28
  • gubernal
  • dimacor
  • betaptin
  • aptolduriles
  • aptine
  • aptin
  • aprobal
  • apllobal

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