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Celiprolol

Celiprolol Structure
Celiprolol
  • CAS No.56980-93-9
  • Chemical Name:Celiprolol
  • CBNumber:CB8411567
  • Molecular Formula:C20H33N3O4
  • Formula Weight:379.49
  • MOL File:56980-93-9.mol
Celiprolol Property
  • Melting point 110-112°
  • Boiling point 586.5±50.0 °C(Predicted)
  • Density 1.114±0.06 g/cm3(Predicted)
  • storage temp. -20°C Freezer, Under Inert Atmosphere
  • solubility Chloroform (slightly), Methanol (Slightly)
  • pka pKa ～9.7 (Uncertain)
  • form Solid
  • color Yellow
  • Water Solubility 22.9mg/L(22.5 ºC)
  • CAS DataBase Reference 56980-93-9(CAS DataBase Reference)
  • FDA UNII DRB57K47QC
  • ATC code C07AB08
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Celiprolol Chemical Properties,Usage,Production

  • Originator Selectol,Chemie Linz,Austria,1983
  • Uses Celiprolol is an intermediate in the synthesis of Celiprolol Hydrochloride (C254500). Celiprolol is a cardioselective β1-adrenergic blocker. Antihypertensive, antianginal.
  • Definition ChEBI: 3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea is an aromatic ketone.
  • Manufacturing Process 3-Acetyl-4-hydroxyaniline, in solution in pyridine, is reacted with dimethylcarbamoyl chloride at room temperature to give N-(3-acetyl-4- hydroxy)phenyl-N'-dimethylurea, which after evaporating the pyridine, taking up the residue in chloroform and evaporating the latter, is obtained in a crystalline form. Melting point: 160°-162°C. After reaction of the product in alkaline aqueous solution, with epichlorohydrin, N-[3-acetyl-4-(2',3'-epoxy)- propoxy]-phenyl-N'-dimethylurea (melting point: 98°-102°C) is obtained, and this, in turn, is reacted with excess tert-butylamine in aqueous solution at room temperature to give N-[3-acetyl-4-(3'-tert-butylamino-2'-hydroxy)- propoxy)-phenyl-N'-dimethylurea of melting point: 120°-122°C.
  • Therapeutic Function Beta-adrenergic blocker
Celiprolol Preparation Products And Raw materials
Raw materials
Preparation Products
Celiprolol Suppliers
Global(21)Suppliers
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Celiprolol Spectrum
56980-93-9, CeliprololRelated Search:
  • C20H33N3O4
  • 56980-93-3
  • 化合物 T20666
  • 西利洛尔
  • 塞利洛尔
  • 3-[3-乙酰-4-(2-羟基-3-叔丁氨基丙氧基)苯基]-1,1-二乙基脲
  • 56980-93-9
  • Edsivo
  • CeliprololQ: What is Celiprolol Q: What is the CAS Number of Celiprolol
  • Celiprolol USP/EP/BP
  • rac-3-[3-Acetyl-4-[(R*)-3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea
  • rac-1,1-Diethyl-3-[3-acetyl-4-[(R*)-2-hydroxy-3-[(1,1-dimethylethyl)amino]propoxy]phenyl]urea
  • Urea, N'-[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethyl-
  • Selectol
  • Racemic Celiprolol
  • dl-Celiprolol
  • (R,S)-Celiprolol
  • CELIPROLOLHYDROCHLORIDE(SUBJECTTOPANTENTFREE)
  • Celiprolol Base
  • CELIPROLOL
  • 3-[3-acetyl-4-(2-hydroxy-3-tert-butylamino-propoxy)-phenyl]-1,1-diethyl-urea
  • n’-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-n,n-di
  • -diethyl-
  • celiptolol

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