Originator
Selectol,Chemie Linz,Austria,1983
Manufacturing Process
3-Acetyl-4-hydroxyaniline, in solution in pyridine, is reacted with
dimethylcarbamoyl chloride at room temperature to give N-(3-acetyl-4-
hydroxy)phenyl-N'-dimethylurea, which after evaporating the pyridine, taking
up the residue in chloroform and evaporating the latter, is obtained in a
crystalline form. Melting point: 160°-162°C. After reaction of the product in
alkaline aqueous solution, with epichlorohydrin, N-[3-acetyl-4-(2',3'-epoxy)-
propoxy]-phenyl-N'-dimethylurea (melting point: 98°-102°C) is obtained, and
this, in turn, is reacted with excess tert-butylamine in aqueous solution at
room temperature to give N-[3-acetyl-4-(3'-tert-butylamino-2'-hydroxy)-
propoxy)-phenyl-N'-dimethylurea of melting point: 120°-122°C.
