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ESTETROL

ESTETROL Structure
ESTETROL
  • CAS No.15183-37-6
  • Chemical Name:ESTETROL
  • CBNumber:CB1210710
  • Molecular Formula:C18H24O4
  • Formula Weight:304.38
  • MOL File:15183-37-6.mol
ESTETROL Property
  • Melting point 233-236°C
  • Boiling point 491.9±45.0 °C(Predicted)
  • Density 1.343±0.06 g/cm3(Predicted)
  • storage temp. -20°C Freezer
  • solubility DMSO: soluble20mg/mL, clear
  • form powder
  • pka 10.22±0.70(Predicted)
  • color white to beige
  • optical activity [α]/D +125 to +135, c = 1 in ethanol
  • FDA UNII ENB39R14VF
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H362-H351-H360
  • Precautionary statements P201-P202-P281-P308+P313-P405-P501-P201-P260-P263-P264-P270-P308+P313
ESTETROL Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1523
  • Product name : Estetrol
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹22819.1
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1523
  • Product name : Estetrol
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹88256.23
  • Updated: 2022/06/14
  • Buy: Buy

ESTETROL Chemical Properties,Usage,Production

  • Chemical Properties Off-White Solid
  • Uses A metabolite of Estradiol. It is an estrogenic steroid synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta.
  • Uses Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium). In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.
  • Definition ChEBI: Estetrol is a 3-hydroxy steroid that is 17beta-estradiol which has been substituted at the 15alpha and 16alpha positions by two additional hydroxy groups. It is a natural estrogen produced exclusively during pregnancy by the fetal liver. It has a role as an estrogen, an estrogen receptor agonist, a human metabolite, a human xenobiotic metabolite and an oral contraceptive. It is a 3-hydroxy steroid, a 17beta-hydroxy steroid, a 16alpha-hydroxy steroid, a 15alpha-hydroxy steroid and a steroid hormone. It derives from a hydride of an estrane.
  • in vivo

    Estetrol (0.6 and 6 mg/kg/day, mixed in diet, 12 weeks) induces an atheroprotective effect in mice, with an ERα‐dependent manner[3].
    Estetrol (0.03-3.0 mg/kg, p.o., twice daily for four consecutive days) inhibits ovulation in rats[5].

    Animal Model:Four‐week‐old ovariectomized ERα+/+LDL‐r?/? or ERα?/?LDL‐r?/? mice were switched to atherogenic diet from the age of 6-18 weeks[1]
    Dosage:0.6 or 6 mg/kg/day
    Administration:mixed in atherogenic diet, 12 weeks
    Result:Decreased total plasma cholesterol at 6 mg/kg/day in ERα+/+LDLr?/? but not in ERα?/?LDLr?/? mice.
    Prevented lipid deposition in ovariectomized ERα+/+LDLr?/? mice.
ESTETROL Preparation Products And Raw materials
Raw materials
Preparation Products
ESTETROL Suppliers
Global(77)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
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  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
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  • Supplier：
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  • Supplier： J & K SCIENTIFIC LTD.
  • Tel： 18210857532
  • Email：jkinfo@jkchemical.com
  • Country：China
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ESTETROL Spectrum
15183-37-6, ESTETROLRelated Search:
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  • Estetrol (E4)
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  • Donesta
  • (8R,9S,13S,14S,15R,16R,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,15,16,17-tetraol
  • 1, 3, 5(10)-ESTRATRIEN-3, 15α, 16α, 17β-TETROL
  • Estra-1,3,5(10)-triene-3,15,16,17-tetrol, (15α,16α,17β)-
  • (8R,9S,13S,14S,15R,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol
  • UBE4A
  • MGC133315
  • KIAA0126
  • 3,15α,16α,17β-Tetrahydroxyestra-1,3,5(10)-triene
  • (15α,16α,17β)-Estra-1,3,5(10)-triene-3,15,16,17-tetrol
  • Estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol
  • 15α-Hydroxyestriol
  • Estra-1,3,5(10)-triene-3,15a,16a,17-tetrol
  • 3,15a,16a,17-Tetrahydroxyestra-1,3,5(10)-triene
  • 15a-Hydroxyestriol
  • (15a,16a,17)-Estra-1,3,5(10)-triene-3,15,16,17-tetrol
  • ESTETROL
  • E 4
  • 15-ALPHA-HYDROXYESTRIOL
  • 1,3,5(10)-ESTRATRIEN-3,15-ALPHA, 16-ALPHA, 17-BETA-TETROL

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