Phosphoramidemustard

Uses

N,N-Bis(2-chloroethyl)phosphorodiamidic Acid Cyclohexylamine Salt is a cytotoxic metabolite of Cyclophosphamide (C988580).

Biological Activity

Phosphoramide mustard cyclohexanamine induces cytotoxicity by forming cross-linked DNA adducts th at hinder DNA strand separation during replication. This compound destroys rapidly dividing cells and leads to DNA damage. In a study with r at ovarian granulosa cells (SIGCs), it reduced cell viability and increased DNA damage response (DDR) gene expression and protein levels. In animal models, it exhibited significant anticancer activity by inhibiting tumor growth. These findings highlight the potential of Phosphoramide mustard cyclohexanamine in cancer research

in vivo