Description
This tremorgenic alkaloid is highly toxic and is elaborated by Aspergillus
jurnigatus. The structure given above has been determined from X-ray crystallography. The crystals are orthorhombic with space group P2 1212 1, a = 14.771,
b = 24.925 and c = 7.321 A with Z = 4. The absolute configuration is based
upon that of L( - )-proline formed by acid hydrolysis of the alkaloid.
Uses
Fumitremorgin B is a tremorgenic mycotoxin. Fumitremorgin B exhibits significant antifungal activities, with MICs of 6.25-50 μg/mL[1][2][3].
Definition
ChEBI: An organic heteropentacyclic compound that is a mycotoxic indole alkaloid produced by several fungi via a tryptophan-proline diketopiperazine intermediate.
References
Yamazaki et al., Tetrahedron Lett., 27 (1975)
