Chemical Properties
White, crystalline solid.Soluble in most organic solvents.
Chemical Properties
Prothoate is an amber to yellow crystalline
solid with a camphor-like odor.
Definition
ChEBI: Prothoate is an organic thiophosphate.
Production Methods
Prothoate is commercially produced by reacting O,O-diethyl phosphorochloridothioate with 1-mercapto-2-propanone in the presence of triethylamine or sodium hydroxide as a base in an aprotic solvent like toluene or dichloromethane, forming the S-(2-oxopropyl) ester intermediate. This is followed by condensation with propylamine under reflux in ethanol or directly in situ to yield prothoate.
General Description
Colorless crystalline solid, with a camphor-like odor. Technical product is an amber to yellow semi-solid. Used as an insecticide and an acaricide.
Reactivity Profile
Organothiophosphates, such as PROTHOATE, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Hazard
Toxic by ingestion and skin absorption,
cholinesterase inhibitor.
Health Hazard
This is a highly toxic material capable of causing death or permanent injury due to exposures during normal use. Small doses at frequent intervals are additive. Similar to parathion.
Fire Hazard
(Non-Specific -- Organophosphorus Pesticide, n.o.s.) Container may explode in heat of fire. Fire and runoff from fire control water may produce irritating or poisonous gases.
Mechanism of action
Acetylcholinesterase (AChE) inhibitor.
Potential Exposure
A potential danger to those involved
in the manufacture, formulation and application of the sys-
temic acaricide and insecticide.
Shipping
UN2783 Organophosphorus pesticides, solid,
toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Incompatibilities
Organophosphates are susceptible to for-
mation of highly toxic and flammable phosphine gas in the
presence of strong reducing agents such as hydrideds and
active metals. Partial oxidation by oxidizing agents may
result in the release of toxic phosphorus oxides
Compounds of the carboxyl group react with all bases, both
inorganic and organic (i.e., amines) releasing substantial
heat, water and a salt that may be harmful. Incompatible
with arsenic compounds (releases hydrogen cyanide gas),
diazo compounds, dithiocarbamates, isocyanates, mercap-
tans, nitrides, and sulfides (releasing heat, toxic and possi-
bly flammable gases), thiosulfates and dithionites (releasing
hydrogen sulfate and oxides of sulfur).
Waste Disposal
In accordance with
40CFR165, follow recommendations for the disposal of
pesticides and pesticide containers. Must be disposed prop-
erly by following package label directions or by contacting
your local or federal environmental control agency, or by
contacting your regional EPA office.
Pesticide Type
Insecticide; Acaricide
