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Gatifloxacinacid

Gatifloxacinacid Structure
Gatifloxacinacid
  • CAS No.121577-32-0
  • Chemical Name:Gatifloxacinacid
  • CBNumber:CB11074612
  • Molecular Formula:C19H22FN3O4.ClH
  • Formula Weight:411.859
  • MOL File:121577-32-0.mol
Gatifloxacinacid Property
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility Soluble in DMSO
  • form Powder
  • color White to off-white
  • FDA UNII C3J4S9UD4E
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Gatifloxacinacid Chemical Properties,Usage,Production

  • Uses Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml)[1]. Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.
  • Biological Activity Gatifloxacin hydrochloride (AM-1155 hydrochloride) is a potent fluoroquinolone antibiotic with broad-spectrum antimicrobial activity.
  • in vivo

    Gatifloxacin hydrochloride (subcutaneous injection; 100 mg/kg; 3 times a day; 30 days) significantly decreases the number of lesions in mouse footpad with Nocardia brasiliensis .

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    Animal Model: Female BALB/c mice with Nocardia brasiliensis in the right hind footpad
    Dosage: 100 mg/kg
    Administration: Subcutaneous injection; 3 times a day; 30 days
    Result: Reduced the production of lesions in mice.
  • target

    Topoisomerase II

    36.7 μM ()

  • IC 50 Quinolone; Topoisomerase II: 36.7 μM ()
  • References [1] Takei M, et al. Inhibitory activities of Gatifloxacin hydrochloride (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases.Antimicrob Agents Chemother.?1998 Oct;42(10):2678-81. DOI:10.1128/AAC.42.10.2678
    [2] Fukuda H, et al. Antibacterial activity of Gatifloxacin hydrochloride (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother.?1998 Aug;42(8):1917-22. DOI:10.1128/AAC.42.8.1917
    [3] Yamada C, et al. Gatifloxacin hydrochloride?acutely?stimulates?insulin?secretion?and?chronically?suppresses?insulin?biosynthesis. Eur J Pharmacol.?2006 Dec 28;553(1-3):67-72. Epub 2006 Sep 28. DOI:10.1016/j.ejphar.2006.09.043
    [4] Daw-Garza A, et al. In?vivo?therapeutic?effect?of?Gatifloxacin mesylate?on?BALB/c?mice?infected?with?Nocardia?brasiliensis.Antimicrob Agents Chemother.?2008 Apr;52(4):1549-50. DOI:10.1128/AAC.00148-08
Gatifloxacinacid Preparation Products And Raw materials
Raw materials
Preparation Products
Gatifloxacinacid Suppliers
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Gatifloxacinacid Spectrum
121577-32-0, GatifloxacinacidRelated Search:
  • 抑制剂
  • 药靶配体
  • C19H22FN3O4ClH
  • 加替沙星盐酸盐,10 MM DMSO 溶液
  • 加替沙星-[D3]盐酸盐/精确称量
  • 化合物GARCINONE D
  • 1-环丙基-6-氟-8-甲氧基-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸盐酸盐
  • 加替沙星盐酸盐
  • 121577-32-0
  • Gatifloxacin hydrochloride, 10 mM in DMSO
  • BMS-206584 (hydrochloride)
  • AM 1155 HYDROCHLORIDE;BMS 206584-01 HYDROCHLORIDE;PD 135432 HYDROCHLORIDE
  • AM 1155 hydrochloride
  • PD 135432 hydrochloride)
  • Gatifloxacin hydrochloride (AM 1155 hydrochloride
  • BMS 206584-01 hydrochloride
  • 3-Quinolinecarboxylicacid,1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(3-Methyl-1-piperazinyl)-4-oxo-,hydrochloride (1:1)
  • 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-Methoxy-7-(3-Methyl-1-piperazinyl)-4-oxo-, Monohydrochloride (9CI)
  • Gatifloxacinacid

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