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CARBOCROMENE HYDROCHLORIDE

CARBOCROMENE HYDROCHLORIDE Property

Safety

Toxicity :LD50 in mice (g/kg): 6.3 orally; 0.528 i.p.; 0.0355 i.v. (Nitz, Potzch)

Hazard and Precautionary Statements (GHS)

CARBOCROMENE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator Intensain,Hoechst,Switz,1963
Uses Vasodilator (coronary).
Definition ChEBI: Carbocromen hydrochloride is a member of coumarins.
Manufacturing Process 18.7 g of 3β-diethylaminoethyl-4-methyl-7-hydroxy-coumarin chlorhydrate are dissolved in 200 cc methyl ethyl ketone and 18 g anhydrous potassium carbonate are added. The mixture is stirred for 1 hour at 70°C and then 12 g bromoacetic acid ethyl ester are allowed to drop in. The reaction mixture is stirred under reflux for 9 hours and then it is filtered off with suction in the heat. The filtrate is concentrated in the vacuum to dryness and the resultant
residue is dissolved in ether. The etheric solution is washed with diluted caustic soda solution for several times and, subsequently, dried with Glauber's salt. By introduction of hydrochloric acid gas into the etheric solution the reaction product is precipitated in the form of chlorhydrate. Yield: 15 g of 3β- diethylaminoethyl-4-methylcoumarin-7-ethyl oxyacetate chlorhydrate having a melting point of 154° to 156°C (= 63% of the theory).
The starting material is produced by reacting resorcinol with 2-(2- diethylaminoethyl)acetic acid ethyl ester.
Therapeutic Function Coronary vasodilator

CARBOCROMENE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CARBOCROMENE HYDROCHLORIDE Spectrum

655-35-6, CARBOCROMENE HYDROCHLORIDERelated Search:

Pharmaceuticals
Intermediates & Fine Chemicals
Heterocycles
Aromatics
Amines
抑制剂
C20H27NO5HCl
化合物 CHROMONAR HYDROCHLORIDE
化合物 T30907
乙胺香豆素盐酸盐
655-35-6
Acetic acid, 2-[[3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]-, ethyl ester, hydrochloride (1:1)
Karbokromen
chromonar HCl
ethyl 2-({3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-c hromen-7-yl}oxy)acetate hydrochloride
CarbochroMen Hydrochloride
Carboc
3-(2-DiethylaMinoethyl)-4-Methyl-7-carbethoxyMethoxy -2-oxo-1,2-chroMene Hydrochloride
2-[[3-[2-(DiethylaMino)ethyl]-4-Methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]acetic Acid Ethyl Ester Hydrochloride
Aids-126445
Aids126445
Acetic acid, {[[3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]ox} Y\]-, ethyl ester, hydrochloride
3[2-(N,N-Diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yloxyacetic acid ethanol ether
intercordin
intensain hydrochloride
carbocromene
carbochromene hydrochloride
antiangor
3-(beta-diethylaminoethyl)-4-methyl-7-(carbethoxymethoxy)-coumarin hydrochlor
ethyl [[3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]acetate hydrochloride
CARBOCROMENE HYDROCHLORIDE