Synthesis
GENERAL METHOD: 4-Bromopentane-2,3-dione (1.79 g, 10.00 mmol) was dissolved in ethanol (50 mL), followed by the addition of thiourea (760 mg, 9.98 mmol). The reaction mixture was stirred at 100 °C for 1 h, after which it was cooled to room temperature. The product was separated by filtration to afford 1-(2-amino-5-methyl-1,3-thiazol-4-yl)ethan-1-one as an off-white solid (1.2 g, 65% yield).LCMS (ESI) analysis showed [M + H]+ = 157.0.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 19, p. 5879 - 5882
[2] Patent: WO2015/52226, 2015, A1. Location in patent: Paragraph 0353
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 6, p. 2760 - 2779
