19(R)-Hydroxy prostaglandin E1

Description

19(R)-hydroxy PGE₁ is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP₁ and EP₃ receptor subtypes, and exhibits contractile activity on smooth muscle preparations. It has an EC₅₀ of 320 nM for contracting guinea pig ileum, which express EP₁ receptors, and an EC₅₀ of 80 nM for contracting chick ileum, which express EP₃ receptors.

Uses

19(R)-hydroxy PGE1 is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP1 and EP3 receptor subtypes, and exhibits contractile activity on smooth muscle preparations. It has an EC50 of 320 nM for contracting guinea pig ileum, which express EP1 receptors, and an EC50 of 80 nM for contracting chick ileum, which express EP3 receptors.

Definition

ChEBI: 19R-Hydroxy-PGE1 is a prostanoid.

References

[1] R. W. KELLY. 19-Hydroxyprostaglandin E1 as a major component of the semen of primates[J]. Nature, 1976, 260 5551: 544-545. DOI: 10.1038/260544a0
[2] D.F. WOODWARD. Identification of 19 (R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist[J]. Prostaglandins, 1993, 46 4: Pages 371-383. DOI: 10.1016/0090-6980(93)90102-d
[3] ERIC P ALLAIN. Inactivation of Prostaglandin E2 as a Mechanism for UGT2B17-Mediated Adverse Effects in Chronic Lymphocytic Leukemia[J]. Frontiers in Oncology, 2019. DOI: 10.3389/fonc.2019.00606
[4] HIROMICHI FUJINO J W R. EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein.[J]. Molecular Pharmacology, 2006, 69 1: 5-10. DOI: 10.1124/mol.105.017749