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(2-Bromoethyl)benzene

CAS No.103-63-9
Chemical Name:(2-Bromoethyl)benzene
CBNumber:CB0427485
Molecular Formula:C8H9Br
Formula Weight:185.06
MOL File:103-63-9.mol

(2-Bromoethyl)benzene Property

Melting point -56 °C
Boiling point 220-221 °C(lit.)
Density 1.355 g/mL at 25 °C(lit.)
refractive index n20/D 1.556(lit.)
Flash point 193 °F
storage temp. 2-8°C
solubility 0.039g/l
form Liquid
color Clear colorless to pale yellow
Water Solubility INSOLUBLE
BRN 507487
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey WMPPDTMATNBGJN-UHFFFAOYSA-N
CAS DataBase Reference 103-63-9(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 96O442668X
NIST Chemistry Reference 1-Bromo-2-phenylethane(103-63-9)
EPA Substance Registry System Benzene, (2-bromoethyl)- (103-63-9)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xn
Risk Statements :22-36-36/37/38
Safety Statements :26-37/39-39
RIDADR :UN 1993 / PGIII
WGK Germany :3
RTECS :CY9032000
TSCA :Yes
HS Code :29036990
Hazardous Substances Data :103-63-9(Hazardous Substances Data)

NFPA 704:

	2
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H319
Precautionary statements P301+P312+P330-P305+P351+P338

(2-Bromoethyl)benzene Price More Price(6)

Brand: Sigma-Aldrich(India)
Product number: B65780
Product name : (2-Bromoethyl)benzene
Purity: 98%
Packaging: 5G
Price: ₹1052.89
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: B65780
Product name : (2-Bromoethyl)benzene
Purity: 98%
Packaging: 100G
Price: ₹2152.2
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: B65780
Product name : (2-Bromoethyl)benzene
Purity: 98%
Packaging: 500G
Price: ₹5623.15
Updated: 2022/06/14
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Brand: TCI Chemicals (India)
Product number: B0594
Product name : (2-Bromoethyl)benzene
Purity: min. 98.0 %
Packaging: 25G
Price: ₹1500
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: B0594
Product name : (2-Bromoethyl)benzene
Purity: min. 98.0 %
Packaging: 100G
Price: ₹2700
Updated: 2022/05/26
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(2-Bromoethyl)benzene Chemical Properties,Usage,Production

Description Phenethylbromide is an analytical reference material that is structurally categorized as an organobromide. It is used in the synthesis of a variety of compounds, including fentanyl. Phenethylbromide is combined with 4-piperidinone to produce N-phenethyl-4-piperidone, which, as a precursor in the synthesis of fentanyl, is scheduled as a List I chemical in the United States. Phenethylbromide may be found as in impurity in samples of fentanyl produced using this pathway.
Chemical Properties colourless to yellow liquid. It is miscible with ether and benzene, but insoluble in water.
Uses (2-Bromoethyl)benzene is used in the preparation of phenelzine by reacting with hydrazine. It is also used as a starting material to prepare various beta-phenethyl derivatives, active pharmaceutical ingredients, and fragrances. It finds application as a flame retardant.
Uses (2-Bromoethyl)benzene is an important starting material for the production of various b-phenethyl derivatives, pharmaceuticals, fragrances, and other fine chemicals.
Preparation (2-Bromoethyl)benzene is synthesized by the reaction of phenethyl alcohol with hydrogen bromide.
Reaction: The phenethyl alcohol was heated to 110°C, hydrogen bromide was slowly introduced, and the reaction was refluxed. The reaction was completed, cooled, washed with water, 10% sodium carbonate solution, and water in turn. After drying with anhydrous potassium carbonate, fractional distillation under reduced pressure was carried out to collect fractions at 97-99°C (2.0 kPa) with a yield of over 90%.
Synthesis Reference(s) The Journal of Organic Chemistry, 29, p. 2317, 1964 DOI: 10.1021/jo01031a051
Synthetic Communications, 20, p. 2349, 1990 DOI: 10.1080/00397919008053179
Safety Store at 2-8° C in a tightly closed container in a dry, well-ventilated place. Containers that are opened must be carefully resealed and kept upright to prevent leakage. (2-Bromoethyl)benzene is incompatible with strong oxidizing agents. This chemical is harmful if swallowed and causes severe eye irritation.
Synthesis Phenethylbromide is commonly synthesized through the addition of HBr to styrene via a free-radical reaction. This process is typically carried out in a glasslined reactor by introducing gaseous HBr into a solution of styrene in an inert solvent that contains a free-radical initiator. The reaction, which is fast and releases a moderate amount of heat, can be managed by introducing HBr at a rate that matches its consumption. Once all the styrene has been converted, any remaining excess HBr can be reclaimed using different methods before the solvent and product are recovered through distillation.
Purification Methods Wash the bromide with conc H2SO4, water, aqueous 10% Na2CO3 and water again, then dry it with CaCl2 and fractionally distil it just before use. [Beilstein 5 IV 907.]
Toxics Screening Level The Initial Threshold Screening Level (ITSL) is 2.7 μg/m3 with an annual averaging time.
References 1. Shukla, P.; Sharma, A.; Pallavi, B.; Cheng, C. H. Nickel-catalyzed reductive Heck type coupling of saturated alkyl halides with acrylates and oxabenzonorbornadiene. Tetrahedron 2015, 71 (15), 2260-2266. DOI:10.1016/J.TET.2015.02.067
2. Huang, Y. B.; Yan, L.; Chen, M. Y.; Guo, Q. X.; Fu, Y. Selective hydrogenolysis of phenols and phenyl ethers to arenes through direct C-O cleavage over ruthenium-tungsten bifunctional catalysts. Green Chem. 2015, 17 (5), 3010-3017. DOI:10.1039/C5GC00326A
3. Justice, D.E.A.D.o. Control of a chemical precursor used in the illicit manufacture of fentanyl as a List I chemical. Final rule. Federal Register 73(144), 43355-43357 (2008). PMID: 18949877