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Valganciclovir hydrochloride

Valganciclovir hydrochloride Structure
Valganciclovir hydrochloride
  • CAS No.175865-59-5
  • Chemical Name:Valganciclovir hydrochloride
  • CBNumber:CB0380410
  • Molecular Formula:C14H23ClN6O5
  • Formula Weight:390.82
  • MOL File:175865-59-5.mol
Valganciclovir hydrochloride Property
  • Melting point 162-164°C
  • storage temp. Keep in dark place,Inert atmosphere,2-8°C
  • solubility H2O: ≥8mg/mL
  • form powder
  • color white to tan
  • Stability Hygroscopic
  • InChIKey ZORWARFPXPVJLW-MTFPJWTKSA-N
  • CAS DataBase Reference 175865-59-5
  • FDA UNII 4P3T9QF9NZ
  • NCI Drug Dictionary Valcyte
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • WGK Germany  :3
  • HS Code  :2933595960
  • NFPA 704:
    0
    1 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H312-H332
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501
Valganciclovir hydrochloride Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0191
  • Product name : Valganciclovir hydrochloride hydrate
  • Purity: ≥98% (HPLC)
  • Packaging: 10MG
  • Price: ₹11288.7
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0191
  • Product name : Valganciclovir hydrochloride hydrate
  • Purity: ≥98% (HPLC)
  • Packaging: 50MG
  • Price: ₹45609.9
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR1626
  • Product name : Valganciclovir Hydrochloride
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 1G
  • Price: ₹15966.88
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: V0158
  • Product name : Valganciclovir Hydrochloride
  • Purity: 
  • Packaging: 250MG
  • Price: ₹2900
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: V0158
  • Product name : Valganciclovir Hydrochloride
  • Purity: 
  • Packaging: 1G
  • Price: ₹6600
  • Updated: 2022/05/26
  • Buy: Buy

Valganciclovir hydrochloride Chemical Properties,Usage,Production

  • Description Valganciclovir hydrochloride, a prodrug of the antiviral ganciclovir, was launched in the US for the oral treatment of cytemegalovirus (CMV) retinitis, a sight-threatening complication in patients with AIDS. This L-Valyl ester prodrug can be prepared in three steps from the nucleoside analog ganciclovir by trimethylsilyl-protection of the amino group, coupling with N-benzyloxycarbonyl-L-valine-N-carboxyanhydride, hydrolysis with hydrochloric acid and hydrogenolysis of the Cbz-protecting group. Valganciclovir is well absorbed and rapidly hydrolyzed to ganciclovir by intracellular esterases in the intestinal mucosal cells and by hepatic esterases. Unlike ganciclovir, valganciclovir was demonstrated to be actively transported by the intestinal peptide transporter PEPT1 in Caco-2 cells. As a consequence, its absolute bioavailability in human was 10-fold higher compared to ganciclovir (6%). In clinical trials, it was shown that a twice-daily 900 mg dose of valganciclovir resulted in similar systemic ganciclovir exposure to 5 mg/kg twice-daily intravenous injection of ganciclovir. Valganciclovir concentrations could not be quantified in most patients within three to four hours. In a randomized non-blind phase III clinical trial, oral valganciclovir (900 mg twice daily for three weeks then 900 mg once daily for one week) was as effective as intravenous ganciclovir (5 mg/kg twice daily for three weeks then 5 mg/kg once daily). Oral treatment with valganciclovir avoided catheter-related infection that sometimes occurred with intravenous ganciclovir.
  • Chemical Properties White Crystalline Solid
  • Originator Roche (Switzerland)
  • Uses Valganciclovir is the valyl ester prodrug of ganciclovir , an antiviral agent used for the treatment of HIV associated retinitis and for the prevention of post transplant cytomegalovirus (CMV) infections. Upon oral administration, intestinal and hepatic esterases rapidly convert valganciclovir to ganciclovir, which can inhibit viral DNA synthesis (IC50 = 0.95 μM) by targeting the CMV polymerase.
  • Uses antibacterial, inhibits protein synthesis
  • Uses Valganciclovir hydrochloride hydrate may be used in HIV-related cell signaling studies.
  • Uses A pro-drug of ganciclovir. Used in treatment of retro-virus
  • brand name Valcyte (Roche).
  • General Description Valganciclovir Hydrochloride is the L-valyl ester of ganciclovir and an antiviral drug, widely used to treat cytomegalovirus infections.
    Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
  • Biochem/physiol Actions Valganciclovir hydrochloride hydrate is an antiviral used to treat cytomegalovirus infection. It is the prodrug of ganciclovir, a synthetic analog of 2′-deoxy-guanosine which is phosphorylated to a dGTP analog that competitively inhibits the incorporation of dGTP by viral DNA polymerase.
  • Side effects Side effects of Valganciclovir hydrochloride include: leukopenia, neutropenia, anaemia, thrombocytopenia, pancytopenia, bone marrow failure and aplastic anaemia. Based on animal data and limited human data, Valganciclovir Oral Solution may temporarily or permanently inhibit spermatogenesis in males and inhibit fertility in females, which in turn may lead to birth defects in humans. It may also cause cancer in humans.
Valganciclovir hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Valganciclovir hydrochloride Suppliers
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Valganciclovir hydrochloride Spectrum
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  • C14H22N6O5ClH
  • C14H22N6O5HCl
  • 缬更昔洛韦杂质 5 盐酸盐(异构体混合物)
  • 缬更昔洛韦盐酸盐,10 MM DMSO 溶液
  • 缬更昔洛韦盐酸盐 A晶
  • 盐酸缬更昔洛
  • 盐酸缬更西昔洛韦
  • (2S)-2-((2-氨基-6-氧代-1H-嘌呤-9(6H)-基)甲氧基)-3-羟丙基 2-氨基-3-甲基丁酸酯盐酸盐
  • 盐酸丙氧西洛韦
  • 缬更昔洛韦盐酸盐水合物
  • 缬更昔洛韦盐酸盐 USP标准品
  • 盐酸缬更昔洛韦
  • (S)-2-氨基-3-甲基丁酸 (R,S)-2-[(2-氨基-6-氧代-1,6-二氢-9H-嘌呤-9-基)甲氧基]-3-羟基丙酯盐酸盐
  • 缬更昔洛韦盐酸盐
  • 175865-59-5
  • Valganciclovir Impurity 5 HCl (Mixture of Isomers)
  • Valganciclovir containing impurity T
  • Valganciclovir for system suitability
  • VALGANCICLOVIR HYDROCHLORIDE USP (NON-STERILE DRUG SUBSTANCE)
  • Valganciclovir hydrochloride, 10 mM in DMSO
  • Valganclicovir hydrochlcnde
  • Valgancyclovir HCL USP
  • 2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]-3-hydroxy-propyl] (2S)-2-amino-3-methyl-butanoate
  • Valganciclovir Hydrochloride L-Valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]- 3-hydroxy propyl ester hydrochloride
  • Valganciclovir hydrochloride salt hydrate
  • VALGANCICLOVIR HCL
  • Valcyte
  • (2S)-2-((2-Amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl 2-amino-3-methylbutanoate hydrochloride
  • Valganciclovir Hydrochloride (1708004)
  • ValganciclovirHydrochlorideQ: What is ValganciclovirHydrochloride Q: What is the CAS Number of ValganciclovirHydrochloride Q: What is the storage condition of ValganciclovirHydrochloride Q: What are the applications of ValganciclovirHydrochloride
  • Valganciclovir D5 hydrochlorideQ: What is Valganciclovir D5 hydrochloride Q: What is the CAS Number of Valganciclovir D5 hydrochloride Q: What is the storage condition of Valganciclovir D5 hydrochloride Q: What are the applications of Valganciclovir D5 hydrochloride

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