ChemicalBook > CAS DataBase List > 8-GINGEROL

8-GINGEROL

CAS No.23513-08-8
Chemical Name:8-GINGEROL
CBNumber:CB0359494
Molecular Formula:C19H30O4
Formula Weight:322.44
MOL File:23513-08-8.mol

8-GINGEROL Property

Boiling point 476.4±35.0 °C(Predicted)
Density 1.058±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility methanol: soluble1mg/mL, clear, colorless
form powder
pka 10.02±0.20(Predicted)
color white to light yellow
Water Solubility practically insoluble in water
BRN 2059802
InChIKey BCIWKKMTBRYQJU-INIZCTEOSA-N
LogP 3.881 (est)
FDA UNII LB0IJB138K
UNSPSC Code 85151701
NACRES NA.25

Safety

Hazard Codes :Xi
Risk Statements :43
Safety Statements :36/37
WGK Germany :3
RTECS :JR4362000
HS Code :29145019

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338

8-GINGEROL Price More Price(3)

Brand: Sigma-Aldrich(India)
Product number: G5923
Product name : [8]-Gingerol
Purity:
Packaging: 5MG
Price: ₹23609.33
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: G5923
Product name : [8]-Gingerol
Purity:
Packaging: 10MG
Price: ₹43830.43
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 01514
Product name : [8]-Gingerol
Purity: analytical standard
Packaging: 10MG
Price: ₹49827.48
Updated: 2022/06/14
Buy: Buy

8-GINGEROL Chemical Properties,Usage,Production

Uses 8-Gingerol has been observed to exhibit anti-oxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation.
Definition ChEBI: (8)-Gingerol is a beta-hydroxy ketone, a member of phenols and a monomethoxybenzene.
Biological Activity [8]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with anti-inflammatory and antioxidant activity.

in vivo

8-Gingerol (50, 100 mg/kg, i.p., once daily for 7 days) can suppress the humoral and cellular immune responses in mice, likely by directly inhibiting activated T cells and B cells^[4]. 8-Gingerol (10, 20 mg/kg, i.p., once daily for 14 days) improves ISO-induced myocardial fibrosis in mice by regulating the PI3K/Akt/mTOR signaling pathway, inhibiting oxidative stress, apoptosis, and autophagy^[5].

Animal Model:	OVA-immunized mice (BALB/c male mice, 5 weeks old, 18-22g, immunized with ovalbumin (OVA))^[4]
Dosage:	25, 50, 100 mg/kg
Administration:	Intraperitoneal injection (i.p.), once daily for 7 consecutive days
Result:	Significantly suppressed LPS-, ConA-, and OVA-induced splenocyte proliferation in OVA-immunized mice and significantly reduced the percentage of CD19+ B cells and CD3+ T cells at high doses (50, 100 mg/kg)

Animal Model:	Isoproterenol (ISO)-induced myocardial fibrosis (MF) mouse model, Kunming mice (male, 6-8 weeks old, 15-20g)^[5]
Dosage:	10 mg/kg (low dose), 20 mg/kg (high dose)
Administration:	Intraperitoneal injection (i.p.), once daily for 14 days
Result:	Significantly reduced the heart weight, left ventricle weight index, CK, LDH levels, ROS generation, and pathological heart damage induced by ISO.