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CGP 42112

CGP 42112 Structure
CGP 42112
  • CAS No.127060-75-7
  • Chemical Name:CGP 42112
  • CBNumber:CB0334084
  • Molecular Formula:C52H69N13O11
  • Formula Weight:1052.18
  • MOL File:127060-75-7.mol
CGP 42112 Property
  • Density 1.39±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility DMSO:350.0(Max Conc. mg/mL);332.64(Max Conc. mM)
  • form solid
  • pka 3.72±0.22(Predicted)
  • color white
  • biological source synthetic
  • Water Solubility Soluble to 1 mg/ml in water
  • BRN 8184948
  • FDA UNII 9Q3V7W3XDD
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
  • F  :10
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
CGP 42112 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: C160
  • Product name : CGP-42112A
  • Purity: ≥95%, synthetic, solid
  • Packaging: 1MG
  • Price: ₹19517.48
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C160
  • Product name : CGP-42112A
  • Purity: ≥95%, synthetic, solid
  • Packaging: 5MG
  • Price: ₹75461.08
  • Updated: 2022/06/14
  • Buy: Buy

CGP 42112 Chemical Properties,Usage,Production

  • Uses CGP-42112A has been used:
    • in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
    • to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
    • as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

  • Definition ChEBI: CGP-42112A is a hexapeptide consisting of L-tyrosine, L-lysine, L-histidine, L-proline and L-isoleucine amino acid residues coupled in sequence and in which the amino group of the L-tyrosyl residue is substituted by a (pyridin-3-ylcarbonyl)nitrilo group and in which the L-lysyl side chain amino group is substituted by a {N(2)-[(benzyloxy)carbonyl]-L-arginyl}nitrilo group. It is a potent angiotensin II receptor type 2 (AT2 receptor) agonist. It has a role as an angiotensin receptor agonist, a vasodilator agent, an antineoplastic agent, an anti-inflammatory agent and a neuroprotective agent. It is an oligopeptide, a benzyl ester and a pyridinecarboxamide.
  • Biochem/physiol Actions Potent AT2 angiotensin II receptor agonist.
  • in vivo

    Intravenous infusions of CGP-42112 (0.1 and 1 mg kg-1 min-1) and PD 123319 (0.36 and 1 mg kg-1 min-1) shifted the upper limit of CBF autoregulation toward higher blood pressures without affecting baseline CBF[3].

  • IC 50 AT2 Receptor; AT1 Receptor
  • storage Store at -20°C
CGP 42112 Preparation Products And Raw materials
Raw materials
Preparation Products
CGP 42112 Suppliers
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CGP 42112 Spectrum
127060-75-7, CGP 42112Related Search:
  • 多肽
  • 目录肽
  • Peptides
  • BioChemical
  • Amino Acids and Peptides
  • Angiotensins
  • Biochemicals and Reagents
  • C52H69N13O11
  • CGP 42112,AT2 RECEPTOR LIGAND
  • (2S,3S)-2-((S)-1-((5S,12S,15S)-15-((1H-咪唑-5-基)甲基)-5-(3-胍丙基)-12-((S)-3-(4-羟基苯基)-2-(烟酰胺基)丙胺基)-3,6,13-三氧代-1-苯基-2-氧代-4,7,14-三氮杂十六烷-16-酰基)吡咯烷-2-甲酰胺)-3-甲基戊酸
  • AT2激动剂多肽CGP42112A
  • 化合物 T14939
  • NICOTINOYL-TYR-LYS(CBA-ARG)-HIS-PRO-ILE-OH
  • CGP-42112游离态
  • CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE
  • 127060-75-7
  • CGP 42112, AT2 receptor ligand
  • CGP 42112 TFA
  • (2S,3S)-2-((S)-1-((5S,12S,15S)-15-((1H-Imidazol-5-yl)methyl)-5-(3-guanidinopropyl)-12-((S)-3-(4-hydroxyphenyl)-2-(nicotinamido)propanamido)-3,6,13-trioxo-1-phenyl-2-oxa-4,7,14-triazahexadecan-16-oyl)pyrrolidine-2-carboxamido)-3-methylpentanoic acid
  • Angiotensin II Receptor Ligand Nicotinoyl-Tyr-Lys(Z-Arg)-His-Pro-Ile-OH
  • CGP-42112A >=95%, synthetic, solid
  • L-Isoleucine, N-(3-pyridinylcarbonyl)-L-tyrosyl-N6-[N2-[(phenylmethoxy)carbonyl]-L-arginyl]-L-lysyl-L-histidyl-L-prolyl-
  • CGP-42112 (CGP42112
  • CGP42112;CGP 42112;CGP-42112A;CGP42112A;CGP 42112A
  • CGP42112A, CGP42112
  • CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE
  • N6-[[(Phenylmethoxy)carbonyl]-L-Arg-]-N2-[[(pyridin-3-yl)carbonyl]-L-Tyr-]-L-Lys-L-His-L-Pro-L-Ile-OH
  • nα-nicotinoyl-tyr-(nα-cbz-arg)-lys-his-pro-ile
  • N-NICOTINOYL-TYR-N-EPSILON(NA-CBZ-ARG)-L YS-HIS-PRO
  • CGP-42112A >98% SYNTHETIC (POTENTANGIOTE NSIN II TYPE A
  • ANGIOTENSIN II RECEPTOR LIGAND
  • ANGIOTENSIN II ANTAGONIST
  • CGP-42112A
  • CGP 42112
  • NIC-TYR-LYS(Z-ARG)-HIS-PRO-ILE
  • NICOTINOYL-TYR-LYS(Z-ARG)-HIS-PRO-ILE-OH
  • NICOTINOYL-TYR-LYS(CBZ-ARG)-HIS-PRO-ILE
  • N-ALPHA-NICOTINOYL-TYR-(N-ALPHA-CBZ-ARG)-LYS-HIS-PRO-ILE-OH
  • N-ALPHA-NICOTINOYL-TYR-LYS(N-ALPHA-CBZ-ARG)-HIS-PRO-ILE
  • [N-ALPHA-(NICOTINOYL-L-TYROSYL)-N-EPSILON-(N-ALPHA-Z-L-ARGINYL)-L-LYSYL]-L HISTIDYL-L-PROLYL-L-ISOLEUCINE

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