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CGP-42112A has been used:

• in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
• to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
• as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

ChEBI:CGP-42112A is a hexapeptide consisting of L-tyrosine, L-lysine, L-histidine, L-proline and L-isoleucine amino acid residues coupled in sequence and in which the amino group of the L-tyrosyl residue is substituted by a (pyridin-3-ylcarbonyl)nitrilo group and in which the L-lysyl side chain amino group is substituted by a {N(2)-[(benzyloxy)carbonyl]-L-arginyl}nitrilo group. It is a potent angiotensin II receptor type 2 (AT2 receptor) agonist. It has a role as an angiotensin receptor agonist, a vasodilator agent, an antineoplastic agent, an anti-inflammatory agent and a neuroprotective agent. It is an oligopeptide, a benzyl ester and a pyridinecarboxamide.

Potent AT2 angiotensin II receptor agonist.

AT2 Receptor; AT1 Receptor

Desiccate at -20°C