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Saikosaponin D

Saikosaponin D Structure
Saikosaponin D
  • CAS No.20874-52-6
  • Chemical Name:Saikosaponin D
  • CBNumber:CB0329374
  • Molecular Formula:C42H68O13
  • Formula Weight:780.99
  • MOL File:20874-52-6.mol
Saikosaponin D Property
  • Melting point 212～218℃
  • Boiling point 893.7±65.0 °C(Predicted)
  • Density 1.36±0.1 g/cm3(Predicted)
  • storage temp. Hygroscopic, Refrigerator, Under inert atmosphere
  • solubility Methanol (Slightly), Pyridine (Slightly)
  • form Solid
  • pka 12.83±0.70(Predicted)
  • color White to Off-White
  • Stability Hygroscopic
  • LogP 3.756 (est)
  • CAS DataBase Reference 20874-52-6
  • EWG's Food Scores 1
  • FDA UNII UR635J3F00
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Safety Statements  :24/25
  • RTECS  :VN3099000
  • HS Code  :29389090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H335-H315-H319
  • Precautionary statements P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

Saikosaponin D Chemical Properties,Usage,Production

  • Description Saikosaponin D is a triterpene saponin found in Bupleurum that exhibits antioxidative, immunomodulatory, anti-fibrotic, anti-angiogenic, anticancer, and chemopreventive activities. Saikosaponin D increases activity of superoxide dismutase, catalase, and glutathione peroxidase and decreases activity of malondialdehyde in cellular models of oxidative damage. In other in vitro models, saikosaponin D increases secretion of IL-12, maturation of dendritic cells, and proliferation of lymphocytes. Saikosaponin D inhibits SERCA, increasing intracellular Ca2+ and inducing autophagy. In vivo, this compound decreases severity of fibrosis. In embryos, saikosaponin D decreases microvessel formation. Additionally, this compound decreases tumor formation in DEN-treated animal models and suppresses expression of CEBP-β and COX-2. Saikosaponin D also induces apoptosis and activation of caspases 3 and 7 in hepatocellular carcinoma cells. Saikosaponin D is a Glucocorticoid receptor agonist. It is a COX-2 and iNOS inhibitor.
  • Uses Saikosaponin d (SSd) is an important active component of Bupleurum scorzonerifolium Willd., a traditional Chinese medicinal herb. Saikosaponins such as Saikosaponin D are used to help analyse and resolve the activities of herbal medicines such as Sho-saiko-to.
  • Uses Saikosaponin D is an inhibitor of proliferation of human prostate cancer cells through arresting the cell cycle.
  • Biological Activity Saikosaponin D inhibits cell growth of human cancer cells by inducing apoptosis and blocking cell cycle progression in the G1 phase. Saikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and CRF release.
  • in vivo

    Saikosaponin D (2 mg/kg/day, i.p.) shows a protective effect on overdose of acetaminophen (APAP)-induced liver injury of mice. Saikosaponin D affects APAP metabolism, increases GSH levels but does not alter PPARα activation. Saikosaponin D (2 mg/kg/day, i.p.) also suppresses APAP-induced increases in the expression of STAT3 target genes and pro-inflammatory cytokines and inhibits APAP-induced activation of STAT3 and NF-kB[2].

  • IC 50 STAT3; NF-κB; ERβ
  • Clinical claims and research We have previously identified a small-molecule, saikosaponin-d (Ssd), that exhibits anti-inflammatory effect via the suppression of NF-κB, NF-AT and AP-1 signaling. We recently showed that Ssd potentiated the anti-cancer potency of TNF-α through NF-κB inhibition. Ssd is one of the major triterpenoid saponins derived from Bupleurum falcatum L. (Umbelliferae), which is commonly prescribed for inflammatory and infectious diseases, and its active component Ssd was reported to have immuno-modulatory, anti-inflammatory, anti-bacterial, anti-viral and anti-cancer activities.
Saikosaponin D Preparation Products And Raw materials
Raw materials
Preparation Products
Saikosaponin D Suppliers
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Saikosaponin D Spectrum
20874-52-6, Saikosaponin DRelated Search:
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  • C48H78O18
  • 20736-52-6
  • SAIKOSAPONIN D 柴胡皂苷D |CAS 20874-52-6
  • 柴胡皂苷D,10 MM DMSO 溶液
  • 柴胡皂苷D/HPLC
  • (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-3,5-二羟基-2-(((3S,4R,4AR,6AR,6BS,8R,8AS,12AR,12BS,14AR,14BS)-8-羟基-4-(羟甲基)-4,6A,6B,11,11,14B-六甲基-1,2,3,4,4A,5,6,6A,6B,7,8,9,10,11,12,12A,14A,14B-十八氢-12B,8A-(环氧甲桥)PICEN-3-基)氧基)-6-甲基四氢-2H-吡喃-4-羟基)-6-(羟甲基)四氢-2H-吡喃-3,4,
  • (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-3,5-二羟基-2-(((3S,4R,4AR,6AR,6BS,8R,8AS,12AR,12BS,14AR,14BS)-8-羟基-4-(羟甲基)-4,6A,6B,11,11,14B-六甲基-1,2,3,4,4A,5,6,6A,6B,7,8,9,10,11,12,12A,14A,14B-十八氢-12B,8A-(环氧甲桥)PICEN-3-基)氧基)-6-甲基四氢-2H-吡喃-4-羟基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇
  • 标准品对照品】SAIKOSAPONIN D
  • 柴胡皂苷D(对照品)
  • 伪- ISOTRIDECYL -蠅- HYDROXY - POLY (OXY-1,2-ETHANEDIYL)
  • 柴胡皂苷DSAIKOSAPONIN D
  • 柴胡提取物(液)
  • SAIKOSAPONIAN D 柴胡皂苷D 标准品
  • 柴胡皂苷 D, 来源于柴胡
  • 柴胡皂苷d
  • 柴胡皂苷D(标准品)
  • 柴胡皂甙D
  • 紫胡皂苷D
  • 柴胡皂苷D 20MG
  • SAIKOSAPONIAN D 柴胡皂苷D
  • 柴胡皂甙E
  • 柴胡皂苷 D
  • 20874-52-6
  • Saikosaponin D, 10 mM in DMSO
  • Saikosaponin D-RM
  • Saikosaponin D(P)
  • (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-3,5-Dihydroxy-2-(((3S,4R,4aR,6aR,6bS,8R,8aS,12aR,12bS,14aR,14bS)-8-hydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,9,10,11,12,12a,14a,14b-octadecahydro-12b,8a-(epoxymethano)picen-3-yl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • β-D-Galactopyranoside, (3β,4α,16α)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-
  • Bupleurum saikosaponin D
  • b-D-Galactopyranoside, (3b,4a,16a)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl 6-deoxy-3-O-b-D-glucopyranosyl-

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