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SCIADOPITYSIN

SCIADOPITYSIN Structure
SCIADOPITYSIN
  • CAS No.521-34-6
  • Chemical Name:SCIADOPITYSIN
  • CBNumber:CB0273404
  • Molecular Formula:C33H24O10
  • Formula Weight:580.54
  • MOL File:521-34-6.mol
SCIADOPITYSIN Property
  • Melting point 296-298°C
  • Boiling point 839.6±65.0 °C(Predicted)
  • Density 1.445±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility Soluble in ethanol and methan
  • form powder
  • pka 6.16±0.40(Predicted)
  • color Light yellow
  • LogP 5.500 (est)
  • CAS DataBase Reference 521-34-6
  • FDA UNII WL44VY201L
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Safety Statements  :24/25
  • HS Code  :29329990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

SCIADOPITYSIN Chemical Properties,Usage,Production

  • Description Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; ) in PC12 cells (EC50 = 9.84 μM). Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells. It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.
  • Uses Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba[1]. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1[2].
  • Definition ChEBI: A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.
  • in vivo

    Sciadopitysin (i.p.; 10 mg/kg; every other day for 8 days) can reverse the bone loss in LPS-induced mice model (C57BL/6 mice; 6 weeks old)[2].

  • target ROS | MMP(e.g.TIMP) | NO | TNF-α | ATPase | cAMP | Beta Amyloid
  • IC 50 NF-κB
  • References [1] Brian?on-Scheid F, et al. HPLC?Separation?and?Quantitative?Determination?of?Biflavones?in?Leaves?from?Ginkgo biloba. Planta Med.?1983 Dec;49(12):204-7. DOI:10.1055/s-2007-969851
    [2] Sciadopitysin?suppresses?RANKL-mediated?osteoclastogenesis?and?prevents?boneloss?in?LPS-treated?mice. Int Immunopharmacol.?2017 Aug;49:109-117. DOI:10.1016/j.intimp.2017.05.029
SCIADOPITYSIN Preparation Products And Raw materials
Raw materials
Preparation Products
SCIADOPITYSIN Suppliers
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SCIADOPITYSIN Spectrum
521-34-6, SCIADOPITYSINRelated Search:
  • Tri-substituted Flavones
  • 黄酮类
  • 抑制剂
  • 药靶配体
  • 标准品-对照品
  • 标准品，对照品
  • 标准品 -中药标准品
  • 黄酮
  • 对照品-中药对照品
  • 对照品
  • 植物提取物
  • 标准品
  • 中药对照品
  • C33H24O10
  • 金松双黄酮,10 MM DMSO 溶液
  • 金松双黄酮对照品
  • 金松双黄酮, 来源于银杏
  • 金松双黄酮(标准品)
  • 金松双黄酮(西阿多黄素)
  • 西阿多黄素
  • 金松双黄酮
  • 521-34-6
  • Sciadopitysin, 10 mM in DMSO
  • Sciadopitysin-RM
  • SCIADOPITYSIN(AS) 10mg
  • Amentoflavone-4',4",7-trimethyl Ether
  • Sciadopitysin, 95%, from Ginkgo biloba L.
  • 4H-1-Benzopyran-4-one,5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-
  • 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)chromen-4-one
  • Nsc 45108
  • Einecs 208-311-5
  • 5,7-Dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-methoxyphenyl)-4-benzopyrone
  • 5,7-Dihydroxy-8-[2-methoxy-5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
  • 5,5'',7''-Trihydroxy-4',4''',7-trimethoxy-3',8''-biflavone
  • 4',4''',7-Trimethoxyamentoflavone
  • 2-(4-Methoxyphenyl)-8-[6-methoxy-3-(4-oxo-5-hydroxy-7-methoxy-4H-1-benzopyran-2-yl)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one
  • 2-(4-Methoxyphenyl)-5,7-dihydroxy-8-[2-methoxy-5-(4-oxo-5-hydroxy-7-methoxy-4H-1-benzopyran-2-yl)phenyl]-4H-1-benzopyran-4-one
  • AMENTOFLAVONE-7,4'',4''-TRIMETHYL ETHER WITH HPLC
  • SCIADOPITYSIN(SH)
  • 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4-benzopyrone
  • SCIADOPITYSIN
  • AMENTOFLAVONE-7,4',4'-TRIMETHYL ETHER
  • AMENTOFLAVONE-7,4',4''-TRIMETHYL ETHER
  • AMENTOFLAVONE-7,4',4'''-TRIMETHYL ETHER

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