Sciadopitysin is a biflavonoid originally isolated from
G. biloba and has diverse biological activities.
1,2,3,4 It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; Item No.
20574) in PC12 cells (EC
50 = 9.84 μM).
2 Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells.
3 It inhibits P-glycoprotein (P-gp; IC
50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel (Item No.
10461) in MDR1-MDCKII cells.
5 Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.
4 
